Human Gene PPM1B (uc002rts.3)
Description: Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1B (PPM1B), transcript variant 4, mRNA.
Transcript (Including UTRs)
Position: hg19 chr2:44,396,000-44,436,571 Size: 40,572 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr2:44,428,339-44,436,486 Size: 8,148 Coding Exon Count: 2
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PPM1B
CDC HuGE Published Literature: PPM1B
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D000082
Acetaminophen
C049325
1,2-dithiol-3-thione
D015632
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
D000086
Acetazolamide
D016604
Aflatoxin B1
D000638
Amiodarone
D000643
Ammonium Chloride
D001564
Benzo(a)pyrene
more ... click here to view the complete list
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00481 - Protein phosphatase 2C
PF07830 - Protein serine/threonine phosphatase 2C, C-terminal domain
SCOP Domains: 81606 - Protein serine/threonine phosphatase 2C, catalytic domain
ModBase Predicted Comparative 3D Structure on O75688-5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
DQ023509 - Homo sapiens PPM1B beta isoform variant 4 (PPM1B) mRNA, complete cds, alternatively spliced.AK056009 - Homo sapiens cDNA FLJ31447 fis, clone NT2NE2000913, highly similar to Protein phosphatase 2C isoform beta (EC 3.1.3.16).DQ023510 - Homo sapiens PPM1B beta isoform variant 5 (PPM1B) mRNA, complete cds, alternatively spliced.AK291214 - Homo sapiens cDNA FLJ77281 complete cds, highly similar to Homo sapiens protein phosphatase 1B (formerly 2C),magnesium-dependent, beta isoform (PPM1B), transcript variant 2,mRNA.DQ023508 - Homo sapiens PPM1B beta isoform variant 2 (PPM1B) mRNA, complete cds, alternatively spliced.DQ023511 - Homo sapiens PPM1B beta isoform variant 6 (PPM1B) mRNA, partial cds, alternatively spliced.BC064381 - Homo sapiens protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform, mRNA (cDNA clone MGC:74583 IMAGE:5734287), complete cds.AJ271832 - Homo sapiens mRNA for protein phosphatase 1B2 (PPM1B2 gene).AJ271835 - Homo sapiens mRNA for protein phosphatase 1B1 (PPM1B1 gene).BC012002 - Homo sapiens protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform, mRNA (cDNA clone IMAGE:4517367), complete cds.AL833035 - Homo sapiens mRNA; cDNA DKFZp666O168 (from clone DKFZp666O168).AB464099 - Synthetic construct DNA, clone: pF1KB8150, Homo sapiens PPM1B gene for protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform, without stop codon, in Flexi system.AJ005801 - Homo sapiens mRNA for protein phosphatase 2C (beta).AF294792 - Homo sapiens Ser/Thr protein phosphatase type 2C beta 2 isoform mRNA, complete cds, alternatively spliced.AF136972 - Homo sapiens protein phosphatase 2C-like protein mRNA, complete cds.JD271926 - Sequence 252950 from Patent EP1572962.JD056799 - Sequence 37823 from Patent EP1572962.JD484754 - Sequence 465778 from Patent EP1572962.JD520869 - Sequence 501893 from Patent EP1572962.JD192223 - Sequence 173247 from Patent EP1572962.JD126461 - Sequence 107485 from Patent EP1572962.JD126462 - Sequence 107486 from Patent EP1572962.JD130548 - Sequence 111572 from Patent EP1572962.JD328839 - Sequence 309863 from Patent EP1572962.JD438591 - Sequence 419615 from Patent EP1572962.HQ448711 - Synthetic construct Homo sapiens clone IMAGE:100072155; CCSB008740_01 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform (PPM1B) gene, encodes complete protein.KJ891861 - Synthetic construct Homo sapiens clone ccsbBroadEn_01255 PPM1B gene, encodes complete protein.
Biochemical and Signaling Pathways
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001033556.1
exon count:
3 CDS single in 3' UTR:
no
RNA size:
1497
ORF size:
984 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2021.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
105 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.