Description: Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1B (PPM1B), transcript variant 1, mRNA. RefSeq Summary (NM_001033557): The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:44,396,000-44,471,523 Size: 75,524 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr2:44,428,339-44,471,522 Size: 43,184 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00481 - Protein phosphatase 2C PF07830 - Protein serine/threonine phosphatase 2C, C-terminal domain
SCOP Domains: 81601 - Protein serine/threonine phosphatase 2C, C-terminal domain 81606 - Protein serine/threonine phosphatase 2C, catalytic domain
ModBase Predicted Comparative 3D Structure on Q4J6C0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.