Human Gene C2orf73 (uc002rxt.1)
  Description: Homo sapiens chromosome 2 open reading frame 73 (C2orf73), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:54,558,071-54,588,714 Size: 30,644 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr2:54,558,113-54,587,699 Size: 29,587 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:54,558,071-54,588,714)mRNA (may differ from genome)Protein (287 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CB073_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C2orf73;
SEQUENCE CAUTION: Sequence=AAH31669.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.41 RPKM in Testis
Total median expression: 25.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.0042-0.381 Picture PostScript Text
3' UTR -226.741015-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15667 - Protein of unknown function with motif GDWWSH

ModBase Predicted Comparative 3D Structure on Q8N5S3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK097617 - Homo sapiens cDNA FLJ40298 fis, clone TESTI2028985.
BC126244 - Homo sapiens chromosome 2 open reading frame 73, mRNA (cDNA clone MGC:161522 IMAGE:8991960), complete cds.
BC126246 - Homo sapiens chromosome 2 open reading frame 73, mRNA (cDNA clone MGC:161524 IMAGE:8991962), complete cds.
BC144191 - Homo sapiens chromosome 2 open reading frame 73, mRNA (cDNA clone IMAGE:9052711), complete cds.
BC144192 - Homo sapiens chromosome 2 open reading frame 73, mRNA (cDNA clone MGC:177729 IMAGE:9052712), complete cds.
JD507531 - Sequence 488555 from Patent EP1572962.
BC031669 - Homo sapiens chromosome 2 open reading frame 73, mRNA (cDNA clone IMAGE:5163761), partial cds.
HQ258071 - Synthetic construct Homo sapiens clone IMAGE:100072380 Unknown protein gene, encodes complete protein.
HQ258566 - Synthetic construct Homo sapiens clone IMAGE:100073080 Unknown protein gene, encodes complete protein.
KJ903755 - Synthetic construct Homo sapiens clone ccsbBroadEn_13149 C2orf73 gene, encodes complete protein.
KJ906418 - Synthetic construct Homo sapiens clone ccsbBroadEn_16088 C2orf73 gene, encodes complete protein.
KJ906419 - Synthetic construct Homo sapiens clone ccsbBroadEn_16089 C2orf73 gene, encodes complete protein.
JD095844 - Sequence 76868 from Patent EP1572962.
JD287558 - Sequence 268582 from Patent EP1572962.
JD291510 - Sequence 272534 from Patent EP1572962.
JD503903 - Sequence 484927 from Patent EP1572962.
JD049573 - Sequence 30597 from Patent EP1572962.
JD050441 - Sequence 31465 from Patent EP1572962.
JD414187 - Sequence 395211 from Patent EP1572962.
JD067614 - Sequence 48638 from Patent EP1572962.
JD451375 - Sequence 432399 from Patent EP1572962.
JD499397 - Sequence 480421 from Patent EP1572962.
JD338832 - Sequence 319856 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AV79, A0AV81, CB073_HUMAN, NM_001100396, NP_001093866, Q8N5S3, Q8N7V4
UCSC ID: uc002rxt.1
RefSeq Accession: NM_001100396
Protein: Q8N5S3 (aka CB073_HUMAN)
CCDS: CCDS46285.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001100396.1
exon count: 5CDS single in 3' UTR: no RNA size: 1921
ORF size: 864CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1925.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.