Description: Homo sapiens interleukin 1 receptor, type II (IL1R2), transcript variant 3, mRNA. RefSeq Summary (NM_001261419): The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]. Transcript (Including UTRs) Position: hg19 chr2:102,608,306-102,641,218 Size: 32,913 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr2:102,625,038-102,641,134 Size: 16,097 Coding Exon Count: 6
ID:IL1R2_HUMAN DESCRIPTION: RecName: Full=Interleukin-1 receptor type 2; Short=IL-1R-2; Short=IL-1RT-2; Short=IL-1RT2; AltName: Full=CD121 antigen-like family member B; AltName: Full=CDw121b; AltName: Full=IL-1 type II receptor; AltName: Full=Interleukin-1 receptor beta; Short=IL-1R-beta; AltName: Full=Interleukin-1 receptor type II; AltName: CD_antigen=CD121b; Contains: RecName: Full=Interleukin-1 receptor type 2, membrane form; Short=mIL-1R2; Short=mIL-1RII; Contains: RecName: Full=Interleukin-1 receptor type 2, soluble form; Short=sIL-1R2; Short=sIL-1RII; Flags: Precursor; FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. SUBUNIT: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex. SUBCELLULAR LOCATION: Isoform Short: Secreted. SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein. PTM: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. SIMILARITY: Belongs to the interleukin-1 receptor family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1r2/";
Behcet Syndrome Elaine F Remmers et al. Nature genetics 2010, , Nature genetics.
[PubMed 20622878]
Colitis, Ulcerative Carl A Anderson et al. Nature genetics 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47., Nature genetics.
[PubMed 21297633]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27930
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC039031 - Homo sapiens interleukin 1 receptor, type II, mRNA (cDNA clone MGC:47725 IMAGE:5723005), complete cds. AK309161 - Homo sapiens cDNA, FLJ99202. AK130412 - Homo sapiens cDNA FLJ26902 fis, clone RCT01275, highly similar to Interleukin-1 receptor, type II precursor. BC027733 - Homo sapiens interleukin 1 receptor, type II, mRNA (cDNA clone IMAGE:4546395), partial cds. BC012346 - Homo sapiens cDNA clone IMAGE:4562827, containing frame-shift errors. U64094 - Human soluble type II interleukin-1 receptor mRNA, complete cds. X59770 - H.sapiens IL-1R2 mRNA for type II interleukin-1 receptor, (cell line CB23). U74649 - Human interleukin-1 receptor type II mRNA, complete cds. CU691642 - Synthetic construct Homo sapiens gateway clone IMAGE:100020922 5' read IL1R2 mRNA. AB590639 - Synthetic construct DNA, clone: pFN21AE1878, Homo sapiens IL1R2 gene for interleukin 1 receptor, type II, without stop codon, in Flexi system. HQ448529 - Synthetic construct Homo sapiens clone IMAGE:100071964; CCSB010293_01 interleukin 1 receptor, type II (IL1R2) gene, encodes complete protein. KJ892439 - Synthetic construct Homo sapiens clone ccsbBroadEn_01833 IL1R2 gene, encodes complete protein. FJ200480 - Homo sapiens interleukin 1 receptor type II variant 3 (IL1R2c) mRNA, complete cds. JD519739 - Sequence 500763 from Patent EP1572962.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
