Description: Homo sapiens four and a half LIM domains 2 (FHL2), transcript variant 5, mRNA. RefSeq Summary (NM_001039492): This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr2:105,977,283-106,015,575 Size: 38,293 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr2:105,977,740-106,002,973 Size: 25,234 Coding Exon Count: 5
ID:FHL2_HUMAN DESCRIPTION: RecName: Full=Four and a half LIM domains protein 2; Short=FHL-2; AltName: Full=LIM domain protein DRAL; AltName: Full=Skeletal muscle LIM-protein 3; Short=SLIM-3; FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. SUBUNIT: Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1. INTERACTION: Self; NbExp=2; IntAct=EBI-701903, EBI-701903; P18847:ATF3; NbExp=3; IntAct=EBI-701903, EBI-712767; Q12778:FOXO1; NbExp=8; IntAct=EBI-701903, EBI-1108782; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-701903, EBI-1802965; Q9NYA1:SPHK1; NbExp=7; IntAct=EBI-701903, EBI-985303; Q9H9D4:ZNF408; NbExp=3; IntAct=EBI-701903, EBI-347633; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in skeletal muscle and heart. DOMAIN: The third LIM zinc-binding mediates interaction with E4F1. SIMILARITY: Contains 4 LIM zinc-binding domains.
Body Mass Index Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
Body Weight Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14192
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
