Description: Homo sapiens solute carrier family 4, sodium bicarbonate transporter, member 10 (SLC4A10), transcript variant 1, mRNA. RefSeq Summary (NM_001178015): This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]. Transcript (Including UTRs) Position: hg19 chr2:162,480,845-162,841,786 Size: 360,942 Total Exon Count: 27 Strand: + Coding Region Position: hg19 chr2:162,481,029-162,834,244 Size: 353,216 Coding Exon Count: 26
ID:S4A10_HUMAN DESCRIPTION: RecName: Full=Sodium-driven chloride bicarbonate exchanger; AltName: Full=Solute carrier family 4 member 10; FUNCTION: Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane (By similarity). SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00955 - HCO3- transporter family PF07565 - Band 3 cytoplasmic domain
SCOP Domains: 55804 - Phoshotransferase/anion transport protein
ModBase Predicted Comparative 3D Structure on Q6U841
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.