Human Gene CERS6 (uc002uec.2)
Description: Homo sapiens ceramide synthase 6 (CERS6), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr2:169,312,759-169,631,644 Size: 318,886 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr2:169,312,959-169,626,172 Size: 313,214 Coding Exon Count: 11
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: Q32M63_HUMAN
DESCRIPTION: SubName: Full=Ceramide synthase 6; SubName: Full=LASS6 protein;
SUBCELLULAR LOCATION: Nucleus (By similarity).SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR016439 - Longevity_assurance_LAG1_LAC1
IPR006634 - TLC-dom
Pfam Domains: PF00046 - Homeobox domain
PF03798 - TLC domain
SCOP Domains: 46689 - Homeodomain-like
ModBase Predicted Comparative 3D Structure on Q32M63
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
KJ904059 - Synthetic construct Homo sapiens clone ccsbBroadEn_13453 CERS6 gene, encodes complete protein.AK172775 - Homo sapiens cDNA FLJ23936 fis, clone COLF1951.BC109284 - Homo sapiens LAG1 homolog, ceramide synthase 6, mRNA (cDNA clone MGC:129949 IMAGE:40031838), complete cds.BC109285 - Homo sapiens LAG1 homolog, ceramide synthase 6, mRNA (cDNA clone MGC:129950 IMAGE:40031840), complete cds.AB527953 - Synthetic construct DNA, clone: pF1KB7648, Homo sapiens LASS6 gene for LAG1 homolog, ceramide synthase 6, without stop codon, in Flexi system.BC030800 - Homo sapiens LAG1 homolog, ceramide synthase 6, mRNA (cDNA clone IMAGE:4396549), complete cds.JD135600 - Sequence 116624 from Patent EP1572962.JD240690 - Sequence 221714 from Patent EP1572962.JD456222 - Sequence 437246 from Patent EP1572962.JD247403 - Sequence 228427 from Patent EP1572962.JD332904 - Sequence 313928 from Patent EP1572962.JD557219 - Sequence 538243 from Patent EP1572962.JD263680 - Sequence 244704 from Patent EP1572962.JD185232 - Sequence 166256 from Patent EP1572962.AK091391 - Homo sapiens cDNA FLJ34072 fis, clone FCBBF3002334.JD183332 - Sequence 164356 from Patent EP1572962.JD166644 - Sequence 147668 from Patent EP1572962.JD553990 - Sequence 535014 from Patent EP1572962.JD350689 - Sequence 331713 from Patent EP1572962.JD039461 - Sequence 20485 from Patent EP1572962.JD385553 - Sequence 366577 from Patent EP1572962.JD429355 - Sequence 410379 from Patent EP1572962.JD339422 - Sequence 320446 from Patent EP1572962.JD315783 - Sequence 296807 from Patent EP1572962.AK023042 - Homo sapiens cDNA FLJ12980 fis, clone NT2RP2006441.JD563152 - Sequence 544176 from Patent EP1572962.JD267112 - Sequence 248136 from Patent EP1572962.JD237340 - Sequence 218364 from Patent EP1572962.JD254148 - Sequence 235172 from Patent EP1572962.JD345808 - Sequence 326832 from Patent EP1572962.AK123214 - Homo sapiens cDNA FLJ41220 fis, clone BRAMY2019554.JD267072 - Sequence 248096 from Patent EP1572962.JD265222 - Sequence 246246 from Patent EP1572962.JD549768 - Sequence 530792 from Patent EP1572962.JD318521 - Sequence 299545 from Patent EP1572962.JD403731 - Sequence 384755 from Patent EP1572962.JD532041 - Sequence 513065 from Patent EP1572962.JD095648 - Sequence 76672 from Patent EP1572962.AK024891 - Homo sapiens cDNA: FLJ21238 fis, clone COL01115.JD331821 - Sequence 312845 from Patent EP1572962.JD046180 - Sequence 27204 from Patent EP1572962.JD554429 - Sequence 535453 from Patent EP1572962.JD134407 - Sequence 115431 from Patent EP1572962.JD562489 - Sequence 543513 from Patent EP1572962.JD133629 - Sequence 114653 from Patent EP1572962.AL080192 - Homo sapiens mRNA; cDNA DKFZp434B102 (from clone DKFZp434B102).U52135 - Human breast cancer genetic suppressor element (Ishmael Lower CP1) mRNA, partial sequence.
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001256126.1
exon count:
11 CDS single in 3' UTR:
no
RNA size:
6868
ORF size:
1179 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2558.00 frame shift in genome:
no
% Coverage:
99.75
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.