Human Gene UGT1A5 (uc002vuw.3)
Description: Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A5 (UGT1A5), mRNA.
RefSeq Summary (NM_019078): This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
Position: hg19 chr2:234,621,638-234,681,951 Size: 60,314 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr2:234,621,638-234,681,205 Size: 59,568 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: UD15_HUMAN
DESCRIPTION: RecName: Full=UDP-glucuronosyltransferase 1-5; Short=UDPGT 1-5; Short=UGT1*5; Short=UGT1-05; Short=UGT1.5; EC=2.4.1.17; AltName: Full=UDP-glucuronosyltransferase 1-E; Short=UGT-1E; Short=UGT1E; AltName: Full=UDP-glucuronosyltransferase 1A5; Flags: Precursor;
FUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.CATALYTIC ACTIVITY: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).SIMILARITY: Belongs to the UDP-glycosyltransferase family.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): UGT1A5
CDC HuGE Published Literature: UGT1A5
Positive Disease Associations: Anemia, Sickle Cell
, Bilirubin
, DNA
, Metabolism
Related Studies: Anemia, Sickle Cell Jacqueline N Milton et al. PloS one 2012, A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia., PloS one.
[PubMed 22558097 ]
Bilirubin Andrew D Johnson et al. Human molecular genetics 2009, Genome-wide association meta-analysis for total serum bilirubin levels., Human molecular genetics.
[PubMed 19414484 ]
Bilirubin Serena Sanna et al. Human molecular genetics 2009, Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia., Human molecular genetics.
[PubMed 19419973 ]
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MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002213 - UDP_glucos_trans
Pfam Domains: PF00201 - UDP-glucoronosyl and UDP-glucosyl transferase
PF04101 - Glycosyltransferase family 28 C-terminal domain
SCOP Domains: 53756 - UDP-Glycosyltransferase/glycogen phosphorylase
ModBase Predicted Comparative 3D Structure on P35504
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
KJ902675 - Synthetic construct Homo sapiens clone ccsbBroadEn_12069 UGT1A4 gene, encodes complete protein.KJ894051 - Synthetic construct Homo sapiens clone ccsbBroadEn_03445 UGT1A1 gene, encodes complete protein.KJ899004 - Synthetic construct Homo sapiens clone ccsbBroadEn_08398 UGT1A4 gene, encodes complete protein.KJ894047 - Synthetic construct Homo sapiens clone ccsbBroadEn_03441 UGT1A9 gene, encodes complete protein.KJ899000 - Synthetic construct Homo sapiens clone ccsbBroadEn_08394 UGT1A6 gene, encodes complete protein.AF462268 - Homo sapiens UDP-glucuronosyltransferase UGT1A8*1 (UGT1A8) mRNA, UGT1A8*1 allele, complete cds.AK313488 - Homo sapiens cDNA, FLJ94041, highly similar to Homo sapiens UDP glycosyltransferase 1 family, polypeptide A8 (UGT1A8), mRNA.AF462267 - Homo sapiens UDP-glucuronosyltransferase UGT1A8*2 (UGT1A8) mRNA, UGT1A8*2 allele, complete cds.BC156848 - Synthetic construct Homo sapiens clone IMAGE:100062577, MGC:190569 UDP glucuronosyltransferase 1 family, polypeptide A8 (UGT1A8) mRNA, encodes complete protein.AF030310 - Homo sapiens UDP-glucuronosyltransferase 1A8 (UGT1A8) mRNA, complete cds.AY435143 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A8 (UGT1A8) mRNA, complete cds.DQ364251 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A8s (UGT1A8S) mRNA, partial cds.BC020971 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:9353 IMAGE:3850654), complete cds.BC069210 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:78613 IMAGE:4660540), complete cds.BC053576 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:61718 IMAGE:4452440), complete cds.HQ257908 - Synthetic construct Homo sapiens clone IMAGE:100072217 Unknown protein gene, encodes complete protein.KJ902667 - Synthetic construct Homo sapiens clone ccsbBroadEn_12061 UGT1A10 gene, encodes complete protein.KR711079 - Synthetic construct Homo sapiens clone CCSBHm_00020087 UGT1A10 (UGT1A10) mRNA, encodes complete protein.KR711080 - Synthetic construct Homo sapiens clone CCSBHm_00020088 UGT1A10 (UGT1A10) mRNA, encodes complete protein.KR711081 - Synthetic construct Homo sapiens clone CCSBHm_00020093 UGT1A10 (UGT1A10) mRNA, encodes complete protein.KR711082 - Synthetic construct Homo sapiens clone CCSBHm_00020115 UGT1A10 (UGT1A10) mRNA, encodes complete protein.KJ904770 - Synthetic construct Homo sapiens clone ccsbBroadEn_14164 UGT1A10 gene, encodes complete protein.U89508 - Human UDP-glucuronosyltransferase 1A10 mRNA, complete cds.AY435137 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A10 (UGT1A10) mRNA, complete cds.AK025403 - Homo sapiens cDNA: FLJ21750 fis, clone COLF5999, highly similar to AF056188 Homo sapiens UDP-glucuronosyltransferase 1A9 (UGT1A9) mRNA.AK313510 - Homo sapiens cDNA, FLJ94068, Homo sapiens UDP glycosyltransferase 1 family, polypeptide A9(UGT1A9), mRNA.BC058844 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A9, mRNA (cDNA clone MGC:61893 IMAGE:4593613), complete cds.BC043491 - Homo sapiens cDNA clone IMAGE:5183433, containing frame-shift errors.AF056188 - Homo sapiens UDP-glucuronosyltransferase 1A9 (UGT1A9) mRNA, complete cds.AY435144 - Homo sapiens UDP glycosyltransferase 1 family polypeptide 9 (UGT1A9) mRNA, complete cds.S55985 - Homo sapiens UDP-glucuronosyltransferase mRNA, complete cds.DQ364246 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A9s (UGT1A9S) mRNA, partial cds.AB527235 - Synthetic construct DNA, clone: pF1KE0362, Homo sapiens UGT1A7 gene for UDP glucuronosyltransferase 1 family, polypeptide A7, without stop codon, in Flexi system.BC146418 - Synthetic construct Homo sapiens clone IMAGE:100015126, MGC:180213 UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7) mRNA, encodes complete protein.BC153172 - Synthetic construct Homo sapiens clone IMAGE:100016516, MGC:184270 UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7) mRNA, encodes complete protein.U89507 - Human UDP-glucuronosyltransferase 1A7 mRNA, complete cds.AY435142 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A7 (UGT1A7) mRNA, complete cds.DQ383513 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A7s (UGT1A7) mRNA, partial cds, alternatively spliced.BC011409 - Homo sapiens cDNA clone IMAGE:3854370, containing frame-shift errors.BC019861 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A6, mRNA (cDNA clone MGC:29860 IMAGE:4454322), complete cds.J04093 - Homo sapiens phenol UDP-glucuronosyltransferase (UDPGT) mRNA, complete cds.DQ364250 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A6s (UGT1A6S) mRNA, complete cds.AY435141 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A6 (UGT1A6) mRNA, complete cds.BC141470 - Synthetic construct Homo sapiens clone IMAGE:100014695, MGC:175337 UDP glucuronosyltransferase 1 family, polypeptide A5 (UGT1A5) mRNA, encodes complete protein.AY435140 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A5 (UGT1A5) mRNA, complete cds.DQ383514 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A5s (UGT1A5) mRNA, partial cds, alternatively spliced.AK313623 - Homo sapiens cDNA, FLJ94193, highly similar to Homo sapiens UDP glycosyltransferase 1 family, polypeptide A4(UGT1A4), mRNA.M57951 - Human bilirubin UDP-glucuronosyltransferase isozyme 2 mRNA, complete cds.BC139784 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A4, mRNA (cDNA clone MGC:156183 IMAGE:40117089), complete cds.DQ364249 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A4s (UGT1A4S) mRNA, complete cds.BC121036 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A4, mRNA (cDNA clone MGC:149704 IMAGE:40117585), complete cds.AY435139 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A4 (UGT1A4) mRNA, complete cds.BC131623 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A4, mRNA (cDNA clone IMAGE:40117575), partial cds.BC166641 - Synthetic construct Homo sapiens clone IMAGE:100066367, MGC:195504 UDP glucuronosyltransferase 1 family, polypeptide A3 (UGT1A3) mRNA, encodes complete protein.AY435138 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A3 (UGT1A3) mRNA, complete cds.DQ364248 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A3s (UGT1A3S) mRNA, partial cds.LF205292 - JP 2014500723-A/12795: Polycomb-Associated Non-Coding RNAs.AK290834 - Homo sapiens cDNA FLJ75264 complete cds, highly similar to Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA.BC128414 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A1, mRNA (cDNA clone MGC:156187 IMAGE:40117598), complete cds.BC128415 - Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A1, mRNA (cDNA clone MGC:156188 IMAGE:40117599), complete cds.M57899 - Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA, complete cds.DQ364247 - Homo sapiens UDP-glucuronosyltransferase 1 family polypeptide A1s (UGT1A1S) mRNA, complete cds.AY435136 - Homo sapiens UDP glycosyltransferase 1 family polypeptide A1 (UGT1A1) mRNA, complete cds.JQ686667 - Homo sapiens UDP-glucuronosyltransferase (UGT1A1) mRNA, complete cds.JQ699637 - Homo sapiens isolate A64S UDP-glucuronosyltransferase 1-1 (BILIQTL1) mRNA, complete cds.JQ699638 - Homo sapiens isolate D70H UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699639 - Homo sapiens isolate G71E UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699640 - Homo sapiens isolate K114K UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699641 - Homo sapiens isolate S143N UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699642 - Homo sapiens isolate D146Y UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699643 - Homo sapiens isolate S191P UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699644 - Homo sapiens isolate R257K UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699645 - Homo sapiens isolate W335R UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699646 - Homo sapiens isolate S343S UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699647 - Homo sapiens isolate T349T UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699649 - Homo sapiens isolate T482T UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.JQ699650 - Homo sapiens isolate L489V UDP-glucuronosyltransferase 1-1 (UDP glucuronosyltransferase 1 family, polypeptide A1) mRNA, complete cds.LF318915 - JP 2014500723-A/126418: Polycomb-Associated Non-Coding RNAs.LF318916 - JP 2014500723-A/126419: Polycomb-Associated Non-Coding RNAs.LF318917 - JP 2014500723-A/126420: Polycomb-Associated Non-Coding RNAs.LF318918 - JP 2014500723-A/126421: Polycomb-Associated Non-Coding RNAs.JD109959 - Sequence 90983 from Patent EP1572962.JD109960 - Sequence 90984 from Patent EP1572962.JD223622 - Sequence 204646 from Patent EP1572962.JD206224 - Sequence 187248 from Patent EP1572962.JD113549 - Sequence 94573 from Patent EP1572962.JD259729 - Sequence 240753 from Patent EP1572962.JD259730 - Sequence 240754 from Patent EP1572962.JD153201 - Sequence 134225 from Patent EP1572962.JD161425 - Sequence 142449 from Patent EP1572962.JD547455 - Sequence 528479 from Patent EP1572962.JD048507 - Sequence 29531 from Patent EP1572962.JD088897 - Sequence 69921 from Patent EP1572962.JD113857 - Sequence 94881 from Patent EP1572962.MA440869 - JP 2018138019-A/12795: Polycomb-Associated Non-Coding RNAs.MA554492 - JP 2018138019-A/126418: Polycomb-Associated Non-Coding RNAs.MA554493 - JP 2018138019-A/126419: Polycomb-Associated Non-Coding RNAs.MA554494 - JP 2018138019-A/126420: Polycomb-Associated Non-Coding RNAs.MA554495 - JP 2018138019-A/126421: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: GNT1, NM_019078, NP_061951, P35504, UD15_HUMAN, UGT1UCSC ID: uc002vuw.3RefSeq Accession: NM_019078
Protein: P35504
(aka UD15_HUMAN)
CCDS: CCDS33404.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_019078.1
exon count:
5 CDS single in 3' UTR:
no
RNA size:
2345
ORF size:
1605 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2624.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.