Description: Homo sapiens mitochondrial antiviral signaling protein (MAVS), transcript variant 2, non-coding RNA. RefSeq Summary (NR_037921): This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020]. Transcript (Including UTRs) Position: hg19 chr20:3,827,446-3,838,615 Size: 11,170 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr20:3,835,272-3,838,581 Size: 3,310 Coding Exon Count: 2
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MAVS CDC HuGE Published Literature: MAVS Positive Disease Associations: Asthma Related Studies:
Asthma Xingnan Li et al. The Journal of allergy and clinical immunology 2010, Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions., The Journal of allergy and clinical immunology.
[PubMed 20159242]
This GWAS confirmed the important role of T(H)2 cytokine and antigen presentation genes in asthma at a genome-wide level and the importance of additional investigation of these 2 regions to delineate their structural complexity and biologic function in the development of asthma.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z434-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK296897 - Homo sapiens cDNA FLJ58074 complete cds, highly similar to Mitochondrial antiviral signaling protein. AB097003 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 031N. AK123956 - Homo sapiens cDNA FLJ41962 fis, clone PUAEN2005588. AK291785 - Homo sapiens cDNA FLJ76894 complete cds. BX649084 - Homo sapiens mRNA; cDNA DKFZp779L0861 (from clone DKFZp779L0861). AK023799 - Homo sapiens cDNA FLJ13737 fis, clone PLACE3000157. AX775775 - Sequence 45 from Patent WO03048202. JD191328 - Sequence 172352 from Patent EP1572962. JD408544 - Sequence 389568 from Patent EP1572962. BC044952 - Homo sapiens virus-induced signaling adapter, mRNA (cDNA clone MGC:50830 IMAGE:5751684), complete cds. AK130992 - Homo sapiens cDNA FLJ27482 fis, clone PCD04339. AB232371 - Homo sapiens Ips-1 mRNA, complete cds. AB033097 - Homo sapiens KIAA1271 mRNA for KIAA1271 protein. JD147806 - Sequence 128830 from Patent EP1572962. CU692246 - Synthetic construct Homo sapiens gateway clone IMAGE:100021498 5' read VISA mRNA. AB463122 - Synthetic construct DNA, clone: pF1KA1271, Homo sapiens MAVS gene for Mitochondrial antiviral-signaling protein, without stop codon, in Flexi system. EU832500 - Synthetic construct Homo sapiens clone HAIB:100067529; DKFZo008F0729 virus-induced signaling adapter protein (VISA) gene, encodes complete protein. EU832581 - Synthetic construct Homo sapiens clone HAIB:100067610; DKFZo004F0730 virus-induced signaling adapter protein (VISA) gene, encodes complete protein. DQ167126 - Homo sapiens virus-induced signaling adapter (VISA) mRNA, complete cds. DQ174270 - Homo sapiens mitochondrial anti-viral signaling protein (MAVS) mRNA, complete cds; nuclear gene for mitochondrial product. DQ181928 - Homo sapiens CARDIF mRNA, complete cds. EF467323 - Homo sapiens virus-induced signaling adaptor variant 1a (VISA) mRNA, complete cds, alternatively spliced. EF467324 - Homo sapiens virus-induced signaling adapter variant 1b (VISA) mRNA, complete cds, alternatively spliced. KC415005 - Homo sapiens mitochondrial antiviral signaling protein (MAVS) mRNA, complete cds; nuclear gene for mitochondrial product.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04622 - RIG-I-like receptor signaling pathway hsa04623 - Cytosolic DNA-sensing pathway
Reactome (by CSHL, EBI, and GO)
Protein Q7Z434 (Reactome details) participates in the following event(s):
R-HSA-168909 viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS R-HSA-936564 NLRX1 inhibits MAVS-DDX58 interaction. R-HSA-168934 MAVS interacts with RIPK1 and FADD R-HSA-918227 Recruitment of TRAF3 to MAVS R-HSA-918230 Recruitment of TRAF6/TRAF2 to IPS-1 R-HSA-990528 Interaction of PCBP2 with MAVS R-HSA-936378 Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS R-HSA-918225 TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 R-HSA-936381 OTUD5 deubiquitinates TRAF3 R-HSA-933526 Recruitment of caspase-8 and -10 to FADD complex R-HSA-990526 Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 R-HSA-933528 Interaction of MEKK1 with TRAF6 R-HSA-933537 Recruitment of TANK to TRAF6 R-HSA-933539 Recruitment of IKK complex R-HSA-918232 Recruitment of IRF3,IRF7 R-HSA-918229 Phosphorylation and release of IRF3/IRF7 R-HSA-933523 Dimerzation of procaspase-8, procaspase-10 R-HSA-933527 Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 R-HSA-933532 Processing of caspases R-HSA-933538 Recruitment of IRF7 to TRAF6 R-HSA-933525 Phosphorylation and release of IRF7 R-HSA-933530 Activation of IKK by MEKK1 R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-168249 Innate Immune System R-HSA-5689896 Ovarian tumor domain proteases R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-168256 Immune System R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
Other Names for This Gene
Alternate Gene Symbols: AK130992, IPS1, KIAA1271, Q7Z434-2, VISA UCSC ID: uc002wjv.3 RefSeq Accession: NR_037921 Protein: Q7Z434-2, splice isoform of Q7Z434
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AK130992.1
exon count:
3
CDS single in 3' UTR:
no
RNA size:
544
ORF size:
417
CDS single in intron:
no
Alignment % ID:
99.82
txCdsPredict score:
864.00
frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
159
# strange splices:
0
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
