Description: Homo sapiens CDK5 regulatory subunit associated protein 1 (CDK5RAP1), transcript variant 5, mRNA. RefSeq Summary (NM_001278168): This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]. Transcript (Including UTRs) Position: hg19 chr20:31,946,647-31,960,955 Size: 14,309 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr20:31,948,115-31,960,613 Size: 12,499 Coding Exon Count: 4
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CDK5RAP1 CDC HuGE Published Literature: CDK5RAP1 Positive Disease Associations: Hair Color
, Iron Related Studies:
Hair Color Nicholas Eriksson et al. PLoS genetics 2010, Web-based, participant-driven studies yield novel genetic associations for common traits., PLoS genetics.
[PubMed 20585627]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5QP51
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
