Description: Homo sapiens engulfment and cell motility 2 (ELMO2), transcript variant 2, mRNA. RefSeq Summary (NM_182764): The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr20:44,994,690-45,011,132 Size: 16,443 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr20:44,995,999-45,008,939 Size: 12,941 Coding Exon Count: 12
ID:ELMO2_HUMAN DESCRIPTION: RecName: Full=Engulfment and cell motility protein 2; AltName: Full=Protein ced-12 homolog A; Short=hCed-12A; FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. SUBUNIT: Interacts with the SH3-domain of DOCK1 via its SH3- binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytosol. Membrane. TISSUE SPECIFICITY: Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. SIMILARITY: Contains 1 ELMO domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAB13879.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14210.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14405.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB47463.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96JJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.