Human Gene UBE2V1 (uc002xvb.4)
  Description: Homo sapiens ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 13, non-coding RNA.
RefSeq Summary (NR_047554): Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012].
Transcript (Including UTRs)
   Position: hg19 chr20:48,697,661-48,729,735 Size: 32,075 Total Exon Count: 3 Strand: -


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:48,697,661-48,729,735)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerH-INVHGNCLynx
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.79 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 68.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC172339 - Synthetic construct Homo sapiens clone IMAGE:100069033, MGC:199044 TMEM189-UBE2V1 readthrough transcript (TMEM189-UBE2V1) mRNA, encodes complete protein.
AB587452 - Synthetic construct DNA, clone: pF1KB7917, Homo sapiens TMEM189-UBE2V1 gene for TMEM189-UBE2V1 readthrough, without stop codon, in Flexi system.
U49278 - Homo sapiens UEV-1 (UBE2V) mRNA, partial cds.
BX647511 - Homo sapiens mRNA; cDNA DKFZp686I21199 (from clone DKFZp686I21199).
BX648147 - Homo sapiens mRNA; cDNA DKFZp686G1080 (from clone DKFZp686G1080).
U97279 - Homo sapiens UEV-1 (UBE2V) alternatively spliced incompletely processed mRNA, partial cds.
AL110132 - Homo sapiens mRNA; cDNA DKFZp564H192 (from clone DKFZp564H192).
JD557645 - Sequence 538669 from Patent EP1572962.
AF049671 - Homo sapiens clone CIR1 cell immortalization-related mRNA sequence.
U39360 - Homo sapiens DNA-binding protein (CROC-1A) mRNA, complete cds.
U39361 - Homo sapiens DNA-binding protein (CROC-1B) mRNA, complete cds.
BC008944 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone IMAGE:2960953), partial cds.
BC000468 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone MGC:8586 IMAGE:2961017), complete cds.
JD273306 - Sequence 254330 from Patent EP1572962.
JD101605 - Sequence 82629 from Patent EP1572962.
JD315254 - Sequence 296278 from Patent EP1572962.
JD558001 - Sequence 539025 from Patent EP1572962.
JD272684 - Sequence 253708 from Patent EP1572962.
JD299451 - Sequence 280475 from Patent EP1572962.
DQ598317 - Homo sapiens piRNA piR-36383, complete sequence.
JD269185 - Sequence 250209 from Patent EP1572962.
JD133135 - Sequence 114159 from Patent EP1572962.
JD104747 - Sequence 85771 from Patent EP1572962.
JD192643 - Sequence 173667 from Patent EP1572962.
JD247296 - Sequence 228320 from Patent EP1572962.
JD413564 - Sequence 394588 from Patent EP1572962.
JD324264 - Sequence 305288 from Patent EP1572962.
JD240731 - Sequence 221755 from Patent EP1572962.
JD083928 - Sequence 64952 from Patent EP1572962.
JD110278 - Sequence 91302 from Patent EP1572962.
JD202857 - Sequence 183881 from Patent EP1572962.
JD377384 - Sequence 358408 from Patent EP1572962.
JD320567 - Sequence 301591 from Patent EP1572962.
JD391827 - Sequence 372851 from Patent EP1572962.
JD433549 - Sequence 414573 from Patent EP1572962.
JD272706 - Sequence 253730 from Patent EP1572962.
JD403675 - Sequence 384699 from Patent EP1572962.
JD253152 - Sequence 234176 from Patent EP1572962.
JD297643 - Sequence 278667 from Patent EP1572962.
JD218720 - Sequence 199744 from Patent EP1572962.
JD054937 - Sequence 35961 from Patent EP1572962.
JD498860 - Sequence 479884 from Patent EP1572962.
JD498861 - Sequence 479885 from Patent EP1572962.
JD241200 - Sequence 222224 from Patent EP1572962.
JD460143 - Sequence 441167 from Patent EP1572962.
JD261094 - Sequence 242118 from Patent EP1572962.
JD261096 - Sequence 242120 from Patent EP1572962.
JD228794 - Sequence 209818 from Patent EP1572962.
JD488233 - Sequence 469257 from Patent EP1572962.
JD268228 - Sequence 249252 from Patent EP1572962.
JD061124 - Sequence 42148 from Patent EP1572962.
BC005215 - Homo sapiens cDNA clone IMAGE:3996506.
U97280 - Homo sapiens UEV1Bs (UBE2V) mRNA, alternatively spliced, partial cds.
AY008273 - Homo sapiens TRAF6-regulated IKK activator 1 beta Uev1A mRNA, complete cds.
U97281 - Homo sapiens UEV1As (UBE2V) mRNA, alternatively spliced, complete cds.
AK314754 - Homo sapiens cDNA, FLJ95620.
BT007382 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1 mRNA, complete cds.
CU674232 - Synthetic construct Homo sapiens gateway clone IMAGE:100017928 5' read UBE2V1 mRNA.
HQ448675 - Synthetic construct Homo sapiens clone IMAGE:100072117; CCSB004673_01 ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) gene, encodes complete protein.
KJ892347 - Synthetic construct Homo sapiens clone ccsbBroadEn_01741 UBE2V1 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_047554, uc002xvb.3
UCSC ID: uc002xvb.4
RefSeq Accession: NR_047554

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: NR_047554.1
exon count: 3CDS single in 3' UTR: no RNA size: 2009
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 496.00frame shift in genome: no % Coverage: 100.00
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.