Human Gene KRTAP23-1 (uc002yny.1)
|
|
Sequence and Links to Tools and Databases
|
|
Comments and Description Text from UniProtKB
|
|
ID: KR231_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 23-1;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. SUBUNIT: Interacts with hair keratins (By similarity).
| |
|
|
Primer design for this transcript
|
|
Comparative Toxicogenomics Database (CTD)
|
|
The following chemicals interact with this gene
| |
|
|
Common Gene Haplotype Alleles
|
|
Press "+" in the title bar above to open this section.
| |
|
|
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
|
|
Microarray Expression Data
|
|
Press "+" in the title bar above to open this section.
| |
|
|
Protein Domain and Structure Information
|
|
InterPro Domains: Graphical view of domain structure IPR007951 - PMG
Pfam Domains: PF05287 - PMG protein
ModBase Predicted Comparative 3D Structure on A1A580
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
| |
|
|
Orthologous Genes in Other Species
|
|
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
| | | | | |
| | | | | |
| | | | | |
| | | | | |
| | | | | |
|
| |
|
|
Gene Ontology (GO) Annotations with Structured Vocabulary
|
|
Descriptions from all associated GenBank mRNAs
|
|
BC128435 - Homo sapiens keratin associated protein 23-1, mRNA (cDNA clone MGC:156230 IMAGE:40119522), complete cds. KJ896037 - Synthetic construct Homo sapiens clone ccsbBroadEn_05431 KRTAP23-1 gene, encodes complete protein.
| |
|
|
Biochemical and Signaling Pathways
|
|
Other Names for This Gene
|
|
Alternate Gene Symbols: A1A580, KAP23.1, KR231_HUMAN, NM_181624, NP_853655 UCSC ID: uc002yny.1 RefSeq Accession: NM_181624
Protein: A1A580
(aka KR231_HUMAN)
CCDS: CCDS33533.1
| |
|
|
Gene Model Information
|
|
category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_181624.1
|
exon count:
| 1 | CDS single in 3' UTR:
| no
| RNA size:
| 208 |
ORF size:
| 198 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 492.00 | frame shift in genome:
| no
| % Coverage:
| 100.00 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
|
Click here
for a detailed description of the fields of the table above.
| |
|
|
Methods, Credits, and Use Restrictions
|
|
Click here
for details on how this gene model was made and data restrictions if any.
| |
|
|
|