Description: Homo sapiens transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1, mRNA. RefSeq Summary (NM_003307): The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]. Transcript (Including UTRs) Position: hg19 chr21:45,770,046-45,862,964 Size: 92,919 Total Exon Count: 33 Strand: + Coding Region Position: hg19 chr21:45,773,584-45,861,700 Size: 88,117 Coding Exon Count: 32
ID:TRPM2_HUMAN DESCRIPTION: RecName: Full=Transient receptor potential cation channel subfamily M member 2; EC=3.6.1.13; AltName: Full=Estrogen-responsive element-associated gene 1 protein; AltName: Full=Long transient receptor potential channel 2; Short=LTrpC-2; Short=LTrpC2; AltName: Full=Transient receptor potential channel 7; Short=TrpC7; FUNCTION: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. CATALYTIC ACTIVITY: ADP-ribose + H(2)O = AMP + D-ribose 5- phosphate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=100 uM for ADP-ribose; Vmax=0.1 umol/min/mg enzyme; SUBUNIT: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. INDUCTION: NAD(+). SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. SIMILARITY: Contains 1 nudix hydrolase domain. SEQUENCE CAUTION: Sequence=BAB64300.1; Type=Frameshift; Positions=1227, 1237; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/trpm2/";
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TRPM2 CDC HuGE Published Literature: TRPM2 Positive Disease Associations: bipolar disorder Related Studies:
bipolar disorder Xu, C. et al. 2005, Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder., American journal of medical genetics Part B, Neuropsychiatric genetics. 2006 Jan;141(1):36-43.
[PubMed 16252251]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94759
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001659 temperature homeostasis GO:0002407 dendritic cell chemotaxis GO:0006811 ion transport GO:0006812 cation transport GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006979 response to oxidative stress GO:0014074 response to purine-containing compound GO:0034220 ion transmembrane transport GO:0035584 calcium-mediated signaling using intracellular calcium source GO:0035725 sodium ion transmembrane transport GO:0043312 neutrophil degranulation GO:0051209 release of sequestered calcium ion into cytosol GO:0051489 regulation of filopodium assembly GO:0055085 transmembrane transport GO:0070301 cellular response to hydrogen peroxide GO:0070588 calcium ion transmembrane transport GO:0071277 cellular response to calcium ion GO:0071415 cellular response to purine-containing compound GO:0071502 cellular response to temperature stimulus GO:0071577 zinc II ion transmembrane transport GO:0097028 dendritic cell differentiation GO:0097553 calcium ion transmembrane import into cytosol GO:0098703 calcium ion import across plasma membrane GO:2000249 regulation of actin cytoskeleton reorganization
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