Description: Homo sapiens pre-B lymphocyte 3 (VPREB3), mRNA. RefSeq Summary (NM_013378): The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]. Transcript (Including UTRs) Position: hg19 chr22:24,094,930-24,096,630 Size: 1,701 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr22:24,095,063-24,096,550 Size: 1,488 Coding Exon Count: 2
ID:VPRE3_HUMAN DESCRIPTION: RecName: Full=Pre-B lymphocyte protein 3; AltName: Full=N27C7-2; AltName: Full=Protein VPreB3; Flags: Precursor; FUNCTION: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. TISSUE SPECIFICITY: Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node. SIMILARITY: Belongs to the immunoglobulin superfamily. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKI3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
