Description: Homo sapiens tuftelin interacting protein 11 (TFIP11), transcript variant 1, mRNA. RefSeq Summary (NM_001008697): This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. Transcript (Including UTRs) Position: hg19 chr22:26,887,894-26,908,437 Size: 20,544 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr22:26,887,979-26,906,238 Size: 18,260 Coding Exon Count: 12
ID:TFP11_HUMAN DESCRIPTION: RecName: Full=Tuftelin-interacting protein 11; AltName: Full=Septin and tuftelin-interacting protein 1; Short=STIP-1; FUNCTION: May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing. SUBUNIT: Interacts with TUFT1 (By similarity). Identified in the spliceosome C complex. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the TFP11/STIP family. SIMILARITY: Contains 1 G-patch domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01585 - G-patch domain PF07842 - GC-rich sequence DNA-binding factor-like protein PF12457 - Tuftelin interacting protein N terminal
ModBase Predicted Comparative 3D Structure on Q9UBB9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000390 spliceosomal complex disassembly GO:0000398 mRNA splicing, via spliceosome GO:0006396 RNA processing GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0031214 biomineral tissue development GO:0031333 negative regulation of protein complex assembly GO:0031848 protection from non-homologous end joining at telomere GO:0032091 negative regulation of protein binding GO:1904876 negative regulation of DNA ligase activity GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining
US Server
