ID:SFI1_HUMAN DESCRIPTION: RecName: Full=Protein SFI1 homolog; Short=hSFI1; FUNCTION: Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. SUBUNIT: Interacts with CETN2 (via C-terminus). INTERACTION: P41208:CETN2; NbExp=4; IntAct=EBI-743371, EBI-1789926; P62136:PPP1CA; NbExp=2; IntAct=EBI-743371, EBI-357253; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localized close to the centriole. DOMAIN: CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2. SIMILARITY: Belongs to the SFI1 family. SIMILARITY: Contains 6 HAT repeats. CAUTION: It is uncertain whether Met-1 or Met-24 is the initiator. SEQUENCE CAUTION: Sequence=AAI10815.1; Type=Erroneous initiation; Sequence=AAI29927.1; Type=Erroneous initiation; Sequence=BAA25468.2; Type=Erroneous initiation; Sequence=CAH70755.2; Type=Erroneous initiation; Sequence=CAI23034.2; Type=Erroneous initiation; Sequence=CAM13202.2; Type=Erroneous initiation; Sequence=CAM14701.1; Type=Erroneous gene model prediction; Sequence=CAM28334.2; Type=Erroneous initiation; Sequence=CAX14857.1; Type=Erroneous initiation; Sequence=CAX14858.1; Type=Erroneous initiation; Sequence=CAX15240.1; Type=Erroneous initiation; Sequence=CAX15241.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A8K8P3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF384701 - JP 2014500723-A/192204: Polycomb-Associated Non-Coding RNAs. AB011114 - Homo sapiens KIAA0542 mRNA for KIAA0542 protein. BC129926 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone MGC:150663 IMAGE:40124134), complete cds. BC129945 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone MGC:156283 IMAGE:40124130), complete cds. AK303362 - Homo sapiens cDNA FLJ57047 complete cds, highly similar to Homo sapiens Sfi1 homolog, spindle assembly associated (yeast) (SFI1), transcript variant 1, mRNA. AK293987 - Homo sapiens cDNA FLJ57048 complete cds, highly similar to Homo sapiens Sfi1 homolog, spindle assembly associated (SFI1), transcript variant 2, mRNA. BC110814 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone MGC:131712 IMAGE:6500257), complete cds. AK292408 - Homo sapiens cDNA FLJ76942 complete cds, highly similar to Homo sapiens Sfi1 homolog, spindle assembly associated (yeast) (SFI1), transcript variant 1, mRNA. BC041101 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone IMAGE:5177555), with apparent retained intron. AB385346 - Synthetic construct DNA, clone: pF1KA0542, Homo sapiens SFI1 gene for spindle assembly associated Sfi1 homolog isoform b, complete cds, without stop codon, in Flexi system. AK055147 - Homo sapiens cDNA FLJ30585 fis, clone BRAWH2007605. MA620278 - JP 2018138019-A/192204: Polycomb-Associated Non-Coding RNAs. BC021576 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone IMAGE:3936711), partial cds. LF206811 - JP 2014500723-A/14314: Polycomb-Associated Non-Coding RNAs. LF358156 - JP 2014500723-A/165659: Polycomb-Associated Non-Coding RNAs. JD334756 - Sequence 315780 from Patent EP1572962. JD118348 - Sequence 99372 from Patent EP1572962. JD251506 - Sequence 232530 from Patent EP1572962. JD465590 - Sequence 446614 from Patent EP1572962. BC033613 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone IMAGE:5172458), with apparent retained intron. AK097004 - Homo sapiens cDNA FLJ39685 fis, clone SMINT2010369. BC046221 - Homo sapiens Sfi1 homolog, spindle assembly associated (yeast), mRNA (cDNA clone IMAGE:6197602), with apparent retained intron. CU689666 - Synthetic construct Homo sapiens gateway clone IMAGE:100016680 5' read SFI1 mRNA. KJ906011 - Synthetic construct Homo sapiens clone ccsbBroadEn_15681 SFI1 gene, encodes complete protein. JD316246 - Sequence 297270 from Patent EP1572962. JD463420 - Sequence 444444 from Patent EP1572962. JD248686 - Sequence 229710 from Patent EP1572962. JD400826 - Sequence 381850 from Patent EP1572962. JD470378 - Sequence 451402 from Patent EP1572962. MA442388 - JP 2018138019-A/14314: Polycomb-Associated Non-Coding RNAs. MA593733 - JP 2018138019-A/165659: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein A8K8P3 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
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