Description: Homo sapiens parvalbumin (PVALB), mRNA. RefSeq Summary (NM_002854): The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. Transcript (Including UTRs) Position: hg19 chr22:37,196,745-37,215,517 Size: 18,773 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr22:37,196,934-37,213,049 Size: 16,116 Coding Exon Count: 4
ID:PRVA_HUMAN DESCRIPTION: RecName: Full=Parvalbumin alpha; FUNCTION: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. MASS SPECTROMETRY: Mass=11927; Mass_error=0.76; Method=Electrospray; Range=2-110; Source=PubMed:10036163; SIMILARITY: Belongs to the parvalbumin family. SIMILARITY: Contains 2 EF-hand domains.
Sexual Dysfunctions, Psychological Andrea Burri et al. PloS one 2012, A genome-wide association study of female sexual dysfunction., PloS one.
[PubMed 22509378]
We report the first GWAS of FSD symptoms in humans. This has pointed to several "risk alleles" and the implication of the serotonin and GABA pathways. Ultimately, understanding key mechanisms via this research may lead to new FSD treatments and inform clinical practice and developments in psychiatric nosology.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20472
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005509 calcium ion binding GO:0042803 protein homodimerization activity GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0051480 regulation of cytosolic calcium ion concentration