Description: Homo sapiens SH3-domain binding protein 1 (SH3BP1), mRNA. RefSeq Summary (NM_018957): This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]. Transcript (Including UTRs) Position: hg19 chr22:38,030,661-38,052,049 Size: 21,389 Total Exon Count: 20 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK124370 - Homo sapiens cDNA FLJ42379 fis, clone UTERU2036089, highly similar to SH3-BINDING PROTEIN 3BP-1. AK126873 - Homo sapiens cDNA FLJ44925 fis, clone BRAMY3014613, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1). AK301163 - Homo sapiens cDNA FLJ61632 complete cds, highly similar to SH3 domain-binding protein 1. CR456576 - Homo sapiens SH3BP1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SH3BP1). AB463257 - Synthetic construct DNA, clone: pF1KB5225, Homo sapiens SH3BP1 gene for SH3-domain binding protein 1, without stop codon, in Flexi system. CU013463 - Homo sapiens SH3BP1, mRNA (cDNA clone IMAGE:100000433), complete cds, without stop codon, in Gateway system. CU013175 - Homo sapiens SH3BP1, mRNA (cDNA clone IMAGE:100000529), complete cds, with stop codon, in Gateway system. AK126556 - Homo sapiens cDNA FLJ44592 fis, clone BLADE2002310, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1). BC008282 - Homo sapiens SH3-domain binding protein 1, mRNA (cDNA clone MGC:10501 IMAGE:3639782), complete cds. JD049654 - Sequence 30678 from Patent EP1572962. JD107349 - Sequence 88373 from Patent EP1572962. JD343746 - Sequence 324770 from Patent EP1572962. AY364241 - Homo sapiens clone peg2155 SH3 domain binding protein 1 (SH3BP1) mRNA, complete cds. JD042725 - Sequence 23749 from Patent EP1572962. JD126866 - Sequence 107890 from Patent EP1572962. DQ892658 - Synthetic construct clone IMAGE:100005288; FLH188722.01X; RZPDo839F0573D SH3-domain binding protein 1 (SH3BP1) gene, encodes complete protein. DQ895898 - Synthetic construct Homo sapiens clone IMAGE:100010358; FLH188718.01L; RZPDo839F0563D SH3-domain binding protein 1 (SH3BP1) gene, encodes complete protein. AL157480 - Homo sapiens mRNA; cDNA DKFZp762E117 (from clone DKFZp762E117). JD437307 - Sequence 418331 from Patent EP1572962.