Human Gene SH3BP1 (uc003atg.1)
  Description: Homo sapiens SH3-domain binding protein 1 (SH3BP1), mRNA.
RefSeq Summary (NM_018957): This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017].
Transcript (Including UTRs)
   Position: hg19 chr22:38,030,661-38,052,049 Size: 21,389 Total Exon Count: 20 Strand: +


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,030,661-38,052,049)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblEntrez GeneExonPrimerGeneNetworkH-INV
HGNCLynxOMIMPubMedWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.06 RPKM in Whole Blood
Total median expression: 279.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK124370 - Homo sapiens cDNA FLJ42379 fis, clone UTERU2036089, highly similar to SH3-BINDING PROTEIN 3BP-1.
AK126873 - Homo sapiens cDNA FLJ44925 fis, clone BRAMY3014613, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1).
AK301163 - Homo sapiens cDNA FLJ61632 complete cds, highly similar to SH3 domain-binding protein 1.
CR456576 - Homo sapiens SH3BP1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SH3BP1).
AB463257 - Synthetic construct DNA, clone: pF1KB5225, Homo sapiens SH3BP1 gene for SH3-domain binding protein 1, without stop codon, in Flexi system.
CU013463 - Homo sapiens SH3BP1, mRNA (cDNA clone IMAGE:100000433), complete cds, without stop codon, in Gateway system.
CU013175 - Homo sapiens SH3BP1, mRNA (cDNA clone IMAGE:100000529), complete cds, with stop codon, in Gateway system.
AK126556 - Homo sapiens cDNA FLJ44592 fis, clone BLADE2002310, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1).
BC008282 - Homo sapiens SH3-domain binding protein 1, mRNA (cDNA clone MGC:10501 IMAGE:3639782), complete cds.
JD049654 - Sequence 30678 from Patent EP1572962.
JD107349 - Sequence 88373 from Patent EP1572962.
JD343746 - Sequence 324770 from Patent EP1572962.
AY364241 - Homo sapiens clone peg2155 SH3 domain binding protein 1 (SH3BP1) mRNA, complete cds.
JD042725 - Sequence 23749 from Patent EP1572962.
JD126866 - Sequence 107890 from Patent EP1572962.
DQ892658 - Synthetic construct clone IMAGE:100005288; FLH188722.01X; RZPDo839F0573D SH3-domain binding protein 1 (SH3BP1) gene, encodes complete protein.
DQ895898 - Synthetic construct Homo sapiens clone IMAGE:100010358; FLH188718.01L; RZPDo839F0563D SH3-domain binding protein 1 (SH3BP1) gene, encodes complete protein.
AL157480 - Homo sapiens mRNA; cDNA DKFZp762E117 (from clone DKFZp762E117).
JD437307 - Sequence 418331 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK124370, NM_018957
UCSC ID: uc003atg.1
RefSeq Accession: NM_018957

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK124370.1
exon count: 20CDS single in 3' UTR: no RNA size: 2858
ORF size: 0CDS single in intron: no Alignment % ID: 99.79
txCdsPredict score: 1731.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.