Description: Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 1, mRNA. RefSeq Summary (NM_001017526): This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr22:45,148,438-45,258,664 Size: 110,227 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr22:45,182,408-45,258,475 Size: 76,068 Coding Exon Count: 12
ID:RHG08_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 8; AltName: Full=Rho-type GTPase-activating protein 8; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). TISSUE SPECIFICITY: Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined. SIMILARITY: Contains 1 CRAL-TRIO domain. SIMILARITY: Contains 1 Rho-GAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P85298
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005096 GTPase activator activity GO:0005515 protein binding
Biological Process: GO:0007165 signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0070374 positive regulation of ERK1 and ERK2 cascade