Description: Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 2, mRNA. RefSeq Summary (NM_181335): This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr22:45,182,337-45,258,664 Size: 76,328 Total Exon Count: 10 Strand: +
Press "+" in the title bar above to open this section.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AL355192 - Novel human gene mapping to chomosome 22. AF195968 - Homo sapiens rho GTPase activating protein 8 isoform 1 (ARHGAP8) mRNA, complete cds. BC132755 - Homo sapiens PRR5-ARHGAP8 fusion, mRNA (cDNA clone MGC:164386 IMAGE:40146777), complete cds. BC132757 - Homo sapiens PRR5-ARHGAP8 fusion, mRNA (cDNA clone MGC:164388 IMAGE:40146779), complete cds. BC144382 - Homo sapiens PRR5-ARHGAP8 fusion, mRNA (cDNA clone MGC:177920 IMAGE:9052903), complete cds. HQ258425 - Synthetic construct Homo sapiens clone IMAGE:100072854 PRR5-ARHGAP8 readthrough (PRR5-ARHGAP8) (PRR5-ARHGAP8) gene, encodes complete protein. KJ904318 - Synthetic construct Homo sapiens clone ccsbBroadEn_13712 PRR5-ARHGAP8 gene, encodes complete protein. AK001306 - Homo sapiens cDNA FLJ10444 fis, clone NT2RP1000825, moderately similar to GTPASE-ACTIVATING PROTEIN RHOGAP. BC059382 - Homo sapiens Rho GTPase activating protein 8, mRNA (cDNA clone IMAGE:30336727), partial cds. BC067824 - Homo sapiens cDNA clone IMAGE:30339826, containing frame-shift errors. BC048280 - Homo sapiens Rho GTPase activating protein 8, mRNA (cDNA clone MGC:54201 IMAGE:5190702), complete cds. AK022305 - Homo sapiens cDNA FLJ12243 fis, clone MAMMA1001305, moderately similar to RHO-GTPASE-ACTIVATING PROTEIN 1. BC010490 - Homo sapiens Rho GTPase activating protein 8, mRNA (cDNA clone IMAGE:2900625), partial cds. AB590903 - Synthetic construct DNA, clone: pFN21AE1927, Homo sapiens ARHGAP8 gene for Rho GTPase activating protein 8, without stop codon, in Flexi system. KJ898538 - Synthetic construct Homo sapiens clone ccsbBroadEn_07932 ARHGAP8 gene, encodes complete protein. AF544240 - Homo sapiens BCH domain-containing Cdc42GAP-like protein (BPGAP1) mRNA, complete cds. AF195969 - Homo sapiens rho GTPase activating protein 8 isoform 2 (AHRGAP8) mRNA, complete cds. JD437433 - Sequence 418457 from Patent EP1572962. JD211273 - Sequence 192297 from Patent EP1572962. JD407380 - Sequence 388404 from Patent EP1572962. JD119659 - Sequence 100683 from Patent EP1572962. JD137836 - Sequence 118860 from Patent EP1572962. JD239619 - Sequence 220643 from Patent EP1572962. JD258372 - Sequence 239396 from Patent EP1572962. JD372024 - Sequence 353048 from Patent EP1572962. JD129837 - Sequence 110861 from Patent EP1572962. JD200200 - Sequence 181224 from Patent EP1572962. JD143926 - Sequence 124950 from Patent EP1572962. JD141094 - Sequence 122118 from Patent EP1572962. JD402221 - Sequence 383245 from Patent EP1572962. BC111953 - Homo sapiens Rho GTPase activating protein 8, mRNA (cDNA clone IMAGE:8327421), partial cds. BC093675 - Homo sapiens Rho GTPase activating protein 8, mRNA (cDNA clone IMAGE:7939520), partial cds.