Human Gene GRIP2 (uc003byv.1)
  Description: Homo sapiens glutamate receptor interacting protein 2 (GRIP2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:14,562,199-14,581,897 Size: 19,699 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr3:14,565,111-14,581,815 Size: 16,705 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:14,562,199-14,581,897)mRNA (may differ from genome)Protein (165 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCHuman Cortex Gene ExpressionLynxMGIPubMedReactome
UniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GRIP2
CDC HuGE Published Literature: GRIP2
Positive Disease Associations: Cognitive performance , Psychomotor Performance
Related Studies:
  1. Cognitive performance
    Need ,et al. 2009, A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery, Human molecular genetics 2009 18- 23 : 4650-61. [PubMed 19734545]
  2. Psychomotor Performance
    Anna C Need et al. Human molecular genetics 2009, A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB., Human molecular genetics. [PubMed 19734545]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.65 RPKM in Heart - Left Ventricle
Total median expression: 55.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.3082-0.418 Picture PostScript Text
3' UTR -1252.082912-0.430 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00595 - PDZ domain (Also known as DHR or GLGF)

SCOP Domains:
50156 - PDZ domain-like

ModBase Predicted Comparative 3D Structure on Q9C0E4-3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AB051506 - Homo sapiens KIAA1719 mRNA for KIAA1719 protein.
AB384271 - Synthetic construct DNA, clone: pF1KSDA1719, Homo sapiens GRIP2 gene for glutamate receptor interacting protein 2, complete cds, without stop codon, in Flexi system.
JD088796 - Sequence 69820 from Patent EP1572962.
AK074145 - Homo sapiens mRNA for FLJ00218 protein.
AK095762 - Homo sapiens cDNA FLJ38443 fis, clone FEBRA2018433, highly similar to Rattus norvegicus glutamate receptor interacting protein 2 (GRIP2) mRNA.
JD159115 - Sequence 140139 from Patent EP1572962.
JD377954 - Sequence 358978 from Patent EP1572962.
JD383359 - Sequence 364383 from Patent EP1572962.
JD209384 - Sequence 190408 from Patent EP1572962.
JD278233 - Sequence 259257 from Patent EP1572962.
JD510873 - Sequence 491897 from Patent EP1572962.
JD084966 - Sequence 65990 from Patent EP1572962.
JD544259 - Sequence 525283 from Patent EP1572962.
JD207250 - Sequence 188274 from Patent EP1572962.
JD138991 - Sequence 120015 from Patent EP1572962.
JD368764 - Sequence 349788 from Patent EP1572962.
JD519801 - Sequence 500825 from Patent EP1572962.
JD057047 - Sequence 38071 from Patent EP1572962.
JD139478 - Sequence 120502 from Patent EP1572962.
JD071534 - Sequence 52558 from Patent EP1572962.
JD206462 - Sequence 187486 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9C0E4 (Reactome details) participates in the following event(s):

R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse
R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors
R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: AK095762, KIAA1719, Q9C0E4-3
UCSC ID: uc003byv.1
RefSeq Accession: NM_001080423
Protein: Q9C0E4-3, splice isoform of Q9C0E4

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK095762.1
exon count: 5CDS single in 3' UTR: no RNA size: 3445
ORF size: 498CDS single in intron: no Alignment % ID: 99.80
txCdsPredict score: 1196.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 2920# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.