Human Gene KLHL18 (uc003crd.3)
  Description: Homo sapiens kelch-like family member 18 (KLHL18), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:47,324,330-47,388,306 Size: 63,977 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr3:47,324,456-47,385,431 Size: 60,976 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:47,324,330-47,388,306)mRNA (may differ from genome)Protein (574 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLH18_HUMAN
DESCRIPTION: RecName: Full=Kelch-like protein 18;
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 6 Kelch repeats.
SEQUENCE CAUTION: Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.29 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 244.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.40126-0.543 Picture PostScript Text
3' UTR -1026.312875-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR015916 - Gal_Oxidase_b-propeller
IPR017096 - Kelch-like_gigaxonin
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13964 - Kelch motif

SCOP Domains:
101898 - NHL repeat
50965 - Galactose oxidase, central domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on O94889
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination

Cellular Component:
GO:0031463 Cul3-RING ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  AK023765 - Homo sapiens cDNA FLJ13703 fis, clone PLACE2000246, weakly similar to RING CANAL PROTEIN.
AK291477 - Homo sapiens cDNA FLJ77309 complete cds, highly similar to Homo sapiens kelch-like 18 (Drosophila) (KLHL18), mRNA.
AK295292 - Homo sapiens cDNA FLJ61265 complete cds, highly similar to Kelch-like protein 18.
JD187447 - Sequence 168471 from Patent EP1572962.
BX537953 - Homo sapiens mRNA; cDNA DKFZp686M0586 (from clone DKFZp686M0586); complete cds.
BC015962 - Homo sapiens kelch-like 18 (Drosophila), mRNA (cDNA clone IMAGE:4081125), partial cds.
JD436576 - Sequence 417600 from Patent EP1572962.
AB527175 - Synthetic construct DNA, clone: pF1KE0309, Homo sapiens KLHL18 gene for kelch-like 18, without stop codon, in Flexi system.
AM393269 - Synthetic construct Homo sapiens clone IMAGE:100002136 for hypothetical protein (KLHL18 gene).
AM393767 - Synthetic construct Homo sapiens clone IMAGE:100002137 for hypothetical protein (KLHL18 gene).
JD527293 - Sequence 508317 from Patent EP1572962.
BC032620 - Homo sapiens kelch-like 18 (Drosophila), mRNA (cDNA clone MGC:44941 IMAGE:5578173), complete cds.
JD448068 - Sequence 429092 from Patent EP1572962.
AB062478 - Homo sapiens OK/SW-cl.74 mRNA, complete cds.
CU689446 - Synthetic construct Homo sapiens gateway clone IMAGE:100019730 5' read KLHL18 mRNA.
KJ902318 - Synthetic construct Homo sapiens clone ccsbBroadEn_11712 KLHL18 gene, encodes complete protein.
AB018338 - Homo sapiens mRNA for KIAA0795 protein, partial cds.
JD544352 - Sequence 525376 from Patent EP1572962.
JD060101 - Sequence 41125 from Patent EP1572962.
DQ585897 - Homo sapiens piRNA piR-53009, complete sequence.
AY714879 - Homo sapiens Kelch-like 18 (KLHL18) mRNA, complete cds, alternatively spliced.
BC016388 - Homo sapiens kelch-like 18 (Drosophila), mRNA (cDNA clone IMAGE:3344095), partial cds.
AK001337 - Homo sapiens cDNA FLJ10475 fis, clone NT2RP2000088, highly similar to Homo sapiens mRNA for KIAA0795 protein.
DQ598518 - Homo sapiens piRNA piR-36584, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K612, KIAA0795, KLH18_HUMAN, NM_025010, NP_079286, O94889, OK/SW-cl.74, Q7Z3E8, Q8N125
UCSC ID: uc003crd.3
RefSeq Accession: NM_025010
Protein: O94889 (aka KLH18_HUMAN or KH18_HUMAN)
CCDS: CCDS33749.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_025010.4
exon count: 10CDS single in 3' UTR: no RNA size: 4743
ORF size: 1725CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3521.00frame shift in genome: no % Coverage: 99.60
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.