Human Gene KLHL18 (uc003crd.3)
Description: Homo sapiens kelch-like family member 18 (KLHL18), mRNA.
Transcript (Including UTRs)
Position: hg19 chr3:47,324,330-47,388,306 Size: 63,977 Total Exon Count: 10 Strand: +
Coding Region
Position: hg19 chr3:47,324,456-47,385,431 Size: 60,976 Coding Exon Count: 10
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: KLH18_HUMAN
DESCRIPTION: RecName: Full=Kelch-like protein 18;
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.SIMILARITY: Contains 1 BTB (POZ) domain.SIMILARITY: Contains 6 Kelch repeats.SEQUENCE CAUTION: Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR015916 - Gal_Oxidase_b-propeller
IPR017096 - Kelch-like_gigaxonin
IPR006652 - Kelch_1
Pfam Domains: PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13964 - Kelch motif
SCOP Domains: 101898 - NHL repeat
50965 - Galactose oxidase, central domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
54695 - POZ domain
ModBase Predicted Comparative 3D Structure on O94889
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding
GO:0004842 ubiquitin-protein transferase activity
Biological Process: GO:0016567 protein ubiquitination
Cellular Component: GO:0031463 Cul3-RING ubiquitin ligase complex
Descriptions from all associated GenBank mRNAs
AK023765 - Homo sapiens cDNA FLJ13703 fis, clone PLACE2000246, weakly similar to RING CANAL PROTEIN.AK291477 - Homo sapiens cDNA FLJ77309 complete cds, highly similar to Homo sapiens kelch-like 18 (Drosophila) (KLHL18), mRNA.AK295292 - Homo sapiens cDNA FLJ61265 complete cds, highly similar to Kelch-like protein 18.JD187447 - Sequence 168471 from Patent EP1572962.BX537953 - Homo sapiens mRNA; cDNA DKFZp686M0586 (from clone DKFZp686M0586); complete cds.BC015962 - Homo sapiens kelch-like 18 (Drosophila), mRNA (cDNA clone IMAGE:4081125), partial cds.JD436576 - Sequence 417600 from Patent EP1572962.AB527175 - Synthetic construct DNA, clone: pF1KE0309, Homo sapiens KLHL18 gene for kelch-like 18, without stop codon, in Flexi system.AM393269 - Synthetic construct Homo sapiens clone IMAGE:100002136 for hypothetical protein (KLHL18 gene).AM393767 - Synthetic construct Homo sapiens clone IMAGE:100002137 for hypothetical protein (KLHL18 gene).JD527293 - Sequence 508317 from Patent EP1572962.BC032620 - Homo sapiens kelch-like 18 (Drosophila), mRNA (cDNA clone MGC:44941 IMAGE:5578173), complete cds.JD448068 - Sequence 429092 from Patent EP1572962.AB062478 - Homo sapiens OK/SW-cl.74 mRNA, complete cds.CU689446 - Synthetic construct Homo sapiens gateway clone IMAGE:100019730 5' read KLHL18 mRNA.KJ902318 - Synthetic construct Homo sapiens clone ccsbBroadEn_11712 KLHL18 gene, encodes complete protein.AB018338 - Homo sapiens mRNA for KIAA0795 protein, partial cds.JD544352 - Sequence 525376 from Patent EP1572962.JD060101 - Sequence 41125 from Patent EP1572962.DQ585897 - Homo sapiens piRNA piR-53009, complete sequence.AY714879 - Homo sapiens Kelch-like 18 (KLHL18) mRNA, complete cds, alternatively spliced.BC016388 - Homo sapiens kelch-like 18 (Drosophila), mRNA (cDNA clone IMAGE:3344095), partial cds.AK001337 - Homo sapiens cDNA FLJ10475 fis, clone NT2RP2000088, highly similar to Homo sapiens mRNA for KIAA0795 protein.DQ598518 - Homo sapiens piRNA piR-36584, complete sequence.
Other Names for This Gene
Alternate Gene Symbols: A8K612, KIAA0795, KLH18_HUMAN, NM_025010, NP_079286, O94889, OK/SW-cl.74, Q7Z3E8, Q8N125UCSC ID: uc003crd.3RefSeq Accession: NM_025010
Protein: O94889
(aka KLH18_HUMAN or KH18_HUMAN)
CCDS: CCDS33749.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_025010.4
exon count:
10 CDS single in 3' UTR:
no
RNA size:
4743
ORF size:
1725 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3521.00 frame shift in genome:
no
% Coverage:
99.60
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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