Description: Homo sapiens chondroitin sulfate proteoglycan 5 (neuroglycan C) (CSPG5), transcript variant 1, mRNA. RefSeq Summary (NM_001206942): The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. Transcript (Including UTRs) Position: hg19 chr3:47,603,728-47,619,623 Size: 15,896 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr3:47,604,090-47,619,101 Size: 15,012 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95196-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC041406 - Homo sapiens chondroitin sulfate proteoglycan 5 (neuroglycan C), mRNA (cDNA clone IMAGE:5284162), with apparent retained intron. AK094639 - Homo sapiens cDNA FLJ37320 fis, clone BRAMY2018106. AF461088 - Homo sapiens chondroitin sulfate proteoglycan 5-II (CSPG5) mRNA, complete cds. AF461087 - Homo sapiens chondroitin sulfate proteoglycan 5-I (CSPG5) mRNA, complete cds. AF461089 - Homo sapiens chondroitin sulfate proteoglycan 5-III (CSPG5) mRNA, complete cds. AF059274 - Homo sapiens neuroglycan C mRNA, complete cds. JD434328 - Sequence 415352 from Patent EP1572962. JD042632 - Sequence 23656 from Patent EP1572962. AK294621 - Homo sapiens cDNA FLJ54649 complete cds, highly similar to Chondroitin sulfate proteoglycan 5 precursor. JD309619 - Sequence 290643 from Patent EP1572962. BC111583 - Synthetic construct Homo sapiens clone IMAGE:40080655, MGC:133443 CSPG5 protein (CSPG5) mRNA, encodes complete protein. AB463496 - Synthetic construct DNA, clone: pF1KB7187, Homo sapiens CSPG5 gene for chondroitin sulfate proteoglycan 5, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95196 (Reactome details) participates in the following event(s):
R-HSA-1878002 XYLTs transfer Xyl to core protein R-HSA-1971487 CHPF,CHSY1,CHSY3 transfer GalNAc to chondroitin R-HSA-1971491 CHPF,CHPF2,CHSY1,CHSY3 transfer GlcA to chondroitin R-HSA-2018659 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 R-HSA-1971483 Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker R-HSA-1971482 The addition of GalNAc to the terminal glucuronate residue forms chondroitin R-HSA-2018682 CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains R-HSA-2022061 Dermatan sulfate can be further sulfated on position 2 of iduronate R-HSA-2022052 Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) R-HSA-2022063 CHST14 transfers SO4(2-) to GalNAc in dermatan or DS R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870 Chondroitin sulfate biosynthesis R-HSA-3595177 Defective CHSY1 causes TPBS R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3595172 Defective CHST3 causes SEDCJD R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-2024101 CS/DS degradation R-HSA-2022923 Dermatan sulfate biosynthesis R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-3781865 Diseases of glycosylation R-HSA-71387 Metabolism of carbohydrates R-HSA-1643685 Disease R-HSA-1430728 Metabolism
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