Human Gene TUSC2 (uc003czz.2)
  Description: Homo sapiens tumor suppressor candidate 2 (TUSC2), mRNA.
RefSeq Summary (NM_007275): This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr3:50,362,341-50,365,668 Size: 3,328 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr3:50,363,608-50,365,530 Size: 1,923 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:50,362,341-50,365,668)mRNA (may differ from genome)Protein (82 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TUSC2_HUMAN
DESCRIPTION: RecName: Full=Tumor suppressor candidate 2; AltName: Full=Fusion 1 protein; Short=Fus-1 protein; AltName: Full=PDGFA-associated protein 2;
FUNCTION: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
INTERACTION: P00521:ABL (xeno); NbExp=1; IntAct=EBI-1052725, EBI-1550592; Q6P2I7:GK006; NbExp=1; IntAct=EBI-1052725, EBI-1047027; O95757:HSPA4L; NbExp=1; IntAct=EBI-1052725, EBI-358652; P50851:LRBA; NbExp=1; IntAct=EBI-1052725, EBI-1052167; Q562F6:SGOL2; NbExp=1; IntAct=EBI-1052725, EBI-989213;
TISSUE SPECIFICITY: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.
PTM: Myristoylation is required for tumor suppressor activity.
SIMILARITY: Belongs to the TUSC2 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TUSC2
Diseases sorted by gene-association score: lung cancer (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.10 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 923.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.40138-0.467 Picture PostScript Text
3' UTR -464.101267-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15000 - Tumour suppressor candidate 2

ModBase Predicted Comparative 3D Structure on O75896
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0001779 natural killer cell differentiation
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007049 cell cycle
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0032618 interleukin-15 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032733 positive regulation of interleukin-10 production
GO:0048469 cell maturation
GO:0050829 defense response to Gram-negative bacterium
GO:0051881 regulation of mitochondrial membrane potential
GO:0052567 response to defense-related host reactive oxygen species production
GO:0070945 neutrophil mediated killing of gram-negative bacterium
GO:0071609 chemokine (C-C motif) ligand 5 production
GO:2000377 regulation of reactive oxygen species metabolic process

Cellular Component:
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  BC023976 - Homo sapiens tumor suppressor candidate 2, mRNA (cDNA clone MGC:1932 IMAGE:3504783), complete cds.
AK124058 - Homo sapiens cDNA FLJ42064 fis, clone SYNOV2005962.
AF055479 - Homo sapiens lung cancer candidate FUS1 (FUS1) mRNA, complete cds.
JD207301 - Sequence 188325 from Patent EP1572962.
JD524069 - Sequence 505093 from Patent EP1572962.
JD302299 - Sequence 283323 from Patent EP1572962.
JD225619 - Sequence 206643 from Patent EP1572962.
JD544746 - Sequence 525770 from Patent EP1572962.
JD365795 - Sequence 346819 from Patent EP1572962.
JD429147 - Sequence 410171 from Patent EP1572962.
JD202219 - Sequence 183243 from Patent EP1572962.
JD201920 - Sequence 182944 from Patent EP1572962.
FW573325 - JP 2010529847-A/46: Oligonucleotides for modulation of target RNA activity.
JD532956 - Sequence 513980 from Patent EP1572962.
JD124612 - Sequence 105636 from Patent EP1572962.
JD220627 - Sequence 201651 from Patent EP1572962.
JD538612 - Sequence 519636 from Patent EP1572962.
JD556150 - Sequence 537174 from Patent EP1572962.
JD504468 - Sequence 485492 from Patent EP1572962.
JD083381 - Sequence 64405 from Patent EP1572962.
JD342538 - Sequence 323562 from Patent EP1572962.
JD078443 - Sequence 59467 from Patent EP1572962.
JD431718 - Sequence 412742 from Patent EP1572962.
JD537227 - Sequence 518251 from Patent EP1572962.
FW573324 - JP 2010529847-A/45: Oligonucleotides for modulation of target RNA activity.
JD123449 - Sequence 104473 from Patent EP1572962.
JD539598 - Sequence 520622 from Patent EP1572962.
JD488768 - Sequence 469792 from Patent EP1572962.
JD388968 - Sequence 369992 from Patent EP1572962.
JD276485 - Sequence 257509 from Patent EP1572962.
JD252529 - Sequence 233553 from Patent EP1572962.
AK311998 - Homo sapiens cDNA, FLJ92272, Homo sapiens tumor suppressor candidate 2 (TUSC2), mRNA.
HQ448135 - Synthetic construct Homo sapiens clone IMAGE:100071518; CCSB012414_02 tumor suppressor candidate 2 (TUSC2) gene, encodes complete protein.
KJ893284 - Synthetic construct Homo sapiens clone ccsbBroadEn_02678 TUSC2 gene, encodes complete protein.
JD460943 - Sequence 441967 from Patent EP1572962.
JD452082 - Sequence 433106 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK124058, B2R4Y9, C3orf11, FUS1, LGCC, O75896, PDAP2, TUSC2_HUMAN, uc003czz.1
UCSC ID: uc003czz.2
RefSeq Accession: NM_007275
Protein: O75896 (aka TUSC2_HUMAN or TUS2_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK124058.1
exon count: 3CDS single in 3' UTR: no RNA size: 1588
ORF size: 249CDS single in intron: no Alignment % ID: 99.87
txCdsPredict score: 656.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.