Human Gene C3orf18 (uc003dar.3)
  Description: Homo sapiens chromosome 3 open reading frame 18 (C3orf18), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:50,595,456-50,605,223 Size: 9,768 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr3:50,597,088-50,603,130 Size: 6,043 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:50,595,456-50,605,223)mRNA (may differ from genome)Protein (162 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CC018_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C3orf18; AltName: Full=Protein G20;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C3orf18
CDC HuGE Published Literature: C3orf18

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.13 RPKM in Brain - Cerebellum
Total median expression: 366.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -293.70581-0.506 Picture PostScript Text
3' UTR -665.141632-0.408 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9UK00
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK124438 - Homo sapiens cDNA FLJ42447 fis, clone BRACE1000186, highly similar to Homo sapiens g20 protein.
BC034766 - Homo sapiens chromosome 3 open reading frame 18, mRNA (cDNA clone MGC:34331 IMAGE:5177784), complete cds.
AL833938 - Homo sapiens mRNA; cDNA DKFZp586G2119 (from clone DKFZp586G2119).
AK130227 - Homo sapiens cDNA FLJ26717 fis, clone PNC03228.
AF188706 - Homo sapiens g20 protein mRNA, complete cds.
JD041182 - Sequence 22206 from Patent EP1572962.
JD466918 - Sequence 447942 from Patent EP1572962.
JD341274 - Sequence 322298 from Patent EP1572962.
JD522215 - Sequence 503239 from Patent EP1572962.
JD067963 - Sequence 48987 from Patent EP1572962.
JD354134 - Sequence 335158 from Patent EP1572962.
JD163321 - Sequence 144345 from Patent EP1572962.
JD424192 - Sequence 405216 from Patent EP1572962.
JD105195 - Sequence 86219 from Patent EP1572962.
JD270437 - Sequence 251461 from Patent EP1572962.
JD126203 - Sequence 107227 from Patent EP1572962.
JD475492 - Sequence 456516 from Patent EP1572962.
JD185820 - Sequence 166844 from Patent EP1572962.
JD409749 - Sequence 390773 from Patent EP1572962.
JD318283 - Sequence 299307 from Patent EP1572962.
JD351110 - Sequence 332134 from Patent EP1572962.
JD260417 - Sequence 241441 from Patent EP1572962.
JD287535 - Sequence 268559 from Patent EP1572962.
JD259223 - Sequence 240247 from Patent EP1572962.
JD108388 - Sequence 89412 from Patent EP1572962.
JD422969 - Sequence 403993 from Patent EP1572962.
JD111118 - Sequence 92142 from Patent EP1572962.
JD119709 - Sequence 100733 from Patent EP1572962.
AK308074 - Homo sapiens cDNA, FLJ98022.
JD408318 - Sequence 389342 from Patent EP1572962.
JD437316 - Sequence 418340 from Patent EP1572962.
JD277210 - Sequence 258234 from Patent EP1572962.
JD341335 - Sequence 322359 from Patent EP1572962.
JD040885 - Sequence 21909 from Patent EP1572962.
JD486588 - Sequence 467612 from Patent EP1572962.
JD171706 - Sequence 152730 from Patent EP1572962.
JD083861 - Sequence 64885 from Patent EP1572962.
AK311093 - Homo sapiens cDNA, FLJ18135.
JD540729 - Sequence 521753 from Patent EP1572962.
AK309486 - Homo sapiens cDNA, FLJ99527.
JD125025 - Sequence 106049 from Patent EP1572962.
JD111531 - Sequence 92555 from Patent EP1572962.
JD133133 - Sequence 114157 from Patent EP1572962.
JD443667 - Sequence 424691 from Patent EP1572962.
JD439061 - Sequence 420085 from Patent EP1572962.
JD465815 - Sequence 446839 from Patent EP1572962.
JD289985 - Sequence 271009 from Patent EP1572962.
JD519636 - Sequence 500660 from Patent EP1572962.
JD416712 - Sequence 397736 from Patent EP1572962.
JD368613 - Sequence 349637 from Patent EP1572962.
AK313128 - Homo sapiens cDNA, FLJ93615, Homo sapiens g20 protein (LOC51161), mRNA.
CU689966 - Synthetic construct Homo sapiens gateway clone IMAGE:100020620 5' read C3orf18 mRNA.
HQ448381 - Synthetic construct Homo sapiens clone IMAGE:100071806; CCSB009343_02 chromosome 3 open reading frame 18 (C3orf18) gene, encodes complete protein.
KJ898841 - Synthetic construct Homo sapiens clone ccsbBroadEn_08235 C3orf18 gene, encodes complete protein.
JD203278 - Sequence 184302 from Patent EP1572962.
JD510258 - Sequence 491282 from Patent EP1572962.
JD552940 - Sequence 533964 from Patent EP1572962.
JD416913 - Sequence 397937 from Patent EP1572962.
JD083871 - Sequence 64895 from Patent EP1572962.
JD365342 - Sequence 346366 from Patent EP1572962.
JD117448 - Sequence 98472 from Patent EP1572962.
JD222209 - Sequence 203233 from Patent EP1572962.
JD144471 - Sequence 125495 from Patent EP1572962.
JD076324 - Sequence 57348 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CC018_HUMAN, NM_016210, NP_057294, Q9UK00
UCSC ID: uc003dar.3
RefSeq Accession: NM_016210
Protein: Q9UK00 (aka CC018_HUMAN)
CCDS: CCDS2829.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_016210.4
exon count: 6CDS single in 3' UTR: no RNA size: 2712
ORF size: 489CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1023.00frame shift in genome: no % Coverage: 99.63
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.