To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CCDC66 CDC HuGE Published Literature: CCDC66 Positive Disease Associations: Hip Related Studies:
Hip Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903296]
The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF15236 - Coiled-coil domain-containing protein 66
ModBase Predicted Comparative 3D Structure on A2RUB6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0046548 retinal rod cell development GO:0050908 detection of light stimulus involved in visual perception GO:0060060 post-embryonic retina morphogenesis in camera-type eye
Descriptions from all associated GenBank mRNAs
BC047509 - Homo sapiens coiled-coil domain containing 66, mRNA (cDNA clone MGC:48472 IMAGE:5276957), complete cds. BC132827 - Homo sapiens coiled-coil domain containing 66, mRNA (cDNA clone MGC:164458 IMAGE:40146849), complete cds. AL833326 - Homo sapiens mRNA; cDNA DKFZp686C0433 (from clone DKFZp686C0433). AL832692 - Homo sapiens mRNA; cDNA DKFZp313G0734 (from clone DKFZp313G0734). HQ258593 - Synthetic construct Homo sapiens clone IMAGE:100073129 Unknown protein gene, encodes complete protein. KJ904153 - Synthetic construct Homo sapiens clone ccsbBroadEn_13547 CCDC66 gene, encodes complete protein. KJ904154 - Synthetic construct Homo sapiens clone ccsbBroadEn_13548 CCDC66 gene, encodes complete protein. AK125303 - Homo sapiens cDNA FLJ43313 fis, clone NT2RI2013357. AK095688 - Homo sapiens cDNA FLJ38369 fis, clone FEBRA2001828. HQ234309 - Homo sapiens clone CCDC66_E10-E4 CCDC66 mRNA, partial sequence. JD348691 - Sequence 329715 from Patent EP1572962. JD050629 - Sequence 31653 from Patent EP1572962. JD363613 - Sequence 344637 from Patent EP1572962. JD073491 - Sequence 54515 from Patent EP1572962. JD248662 - Sequence 229686 from Patent EP1572962. JD036738 - Sequence 17762 from Patent EP1572962. JD375886 - Sequence 356910 from Patent EP1572962. JD234456 - Sequence 215480 from Patent EP1572962. JD284114 - Sequence 265138 from Patent EP1572962. JD236966 - Sequence 217990 from Patent EP1572962. AK096754 - Homo sapiens cDNA FLJ39435 fis, clone PROST2004727. AL832556 - Homo sapiens mRNA; cDNA DKFZp547B2318 (from clone DKFZp547B2318). JD090461 - Sequence 71485 from Patent EP1572962.