ID:F107A_HUMAN DESCRIPTION: RecName: Full=Protein FAM107A; AltName: Full=Down-regulated in renal cell carcinoma 1; AltName: Full=Protein TU3A; FUNCTION: When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development. INTERACTION: P81605:DCD; NbExp=1; IntAct=EBI-743396, EBI-395625; P63151:PPP2R2A; NbExp=1; IntAct=EBI-743396, EBI-1048931; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed in normal tissues. Expression is reduced or absent in a number of cancer cell lines. SIMILARITY: Belongs to the FAM107 family.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): FAM107A CDC HuGE Published Literature: FAM107A Positive Disease Associations: Arthritis, Rheumatoid Related Studies:
Arthritis, Rheumatoid Eli A Stahl et al. Nature genetics 2010, Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., Nature genetics.
[PubMed 20453842]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06625 - Protein of unknown function (DUF1151)
ModBase Predicted Comparative 3D Structure on O95990
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.