Human Gene GOLGB1 (uc003eei.5)
Description: Homo sapiens golgin B1 (GOLGB1), transcript variant 2, mRNA.
Transcript (Including UTRs)
Position: hg19 chr3:121,382,046-121,468,614 Size: 86,569 Total Exon Count: 22 Strand: -
Coding Region
Position: hg19 chr3:121,383,327-121,449,818 Size: 66,492 Coding Exon Count: 21
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: GOGB1_HUMAN
DESCRIPTION: RecName: Full=Golgin subfamily B member 1; AltName: Full=372 kDa Golgi complex-associated protein; Short=GCP372; AltName: Full=Giantin; AltName: Full=Macrogolgin;
FUNCTION: May participate in forming intercisternal cross-bridges of the Golgi complex.SUBUNIT: Homodimer; disulfide-linked. Interacts with PLK3.INTERACTION: P35080:PFN2; NbExp=2; IntAct=EBI-709973, EBI-473138;SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type I membrane protein.MISCELLANEOUS: Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR026202 - GOLGB1
SCOP Domains: 46966 - Spectrin repeat
ModBase Predicted Comparative 3D Structure on Q14789
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF210605 - JP 2014500723-A/18108: Polycomb-Associated Non-Coding RNAs.BX537520 - Homo sapiens mRNA; cDNA DKFZp686F09142 (from clone DKFZp686F09142).AB371588 - Homo sapiens GOLGB1 mRNA for golgin B1, splicing variant, complete cds, clone: HP08164-ARiS161G17c.AB593126 - Homo sapiens GOLGB1 mRNA for Golgin subfamily B member 1, complete cds, clone: HP08164-RBdS040G23.LF339224 - JP 2014500723-A/146727: Polycomb-Associated Non-Coding RNAs.D25542 - Homo sapiens mRNA for golgi antigen gcp372, complete cds.X75304 - H.sapiens giantin mRNA.JD074170 - Sequence 55194 from Patent EP1572962.AK094551 - Homo sapiens cDNA FLJ37232 fis, clone BRAMY2001114.JD202165 - Sequence 183189 from Patent EP1572962.JD181984 - Sequence 163008 from Patent EP1572962.JD122927 - Sequence 103951 from Patent EP1572962.JD563111 - Sequence 544135 from Patent EP1572962.JD375872 - Sequence 356896 from Patent EP1572962.LF339223 - JP 2014500723-A/146726: Polycomb-Associated Non-Coding RNAs.LF339222 - JP 2014500723-A/146725: Polycomb-Associated Non-Coding RNAs.LF339220 - JP 2014500723-A/146723: Polycomb-Associated Non-Coding RNAs.LF339219 - JP 2014500723-A/146722: Polycomb-Associated Non-Coding RNAs.LF339218 - JP 2014500723-A/146721: Polycomb-Associated Non-Coding RNAs.LF339217 - JP 2014500723-A/146720: Polycomb-Associated Non-Coding RNAs.LF339216 - JP 2014500723-A/146719: Polycomb-Associated Non-Coding RNAs.LF339215 - JP 2014500723-A/146718: Polycomb-Associated Non-Coding RNAs.LF339214 - JP 2014500723-A/146717: Polycomb-Associated Non-Coding RNAs.LF339213 - JP 2014500723-A/146716: Polycomb-Associated Non-Coding RNAs.BC057227 - Homo sapiens golgin B1, golgi integral membrane protein, mRNA (cDNA clone IMAGE:4702419), partial cds.LF339211 - JP 2014500723-A/146714: Polycomb-Associated Non-Coding RNAs.LF339210 - JP 2014500723-A/146713: Polycomb-Associated Non-Coding RNAs.LF339209 - JP 2014500723-A/146712: Polycomb-Associated Non-Coding RNAs.LF339208 - JP 2014500723-A/146711: Polycomb-Associated Non-Coding RNAs.LF339207 - JP 2014500723-A/146710: Polycomb-Associated Non-Coding RNAs.LF339206 - JP 2014500723-A/146709: Polycomb-Associated Non-Coding RNAs.LF339205 - JP 2014500723-A/146708: Polycomb-Associated Non-Coding RNAs.LF339204 - JP 2014500723-A/146707: Polycomb-Associated Non-Coding RNAs.LF339203 - JP 2014500723-A/146706: Polycomb-Associated Non-Coding RNAs.BC065301 - Homo sapiens golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1, mRNA (cDNA clone IMAGE:6157315).LF339202 - JP 2014500723-A/146705: Polycomb-Associated Non-Coding RNAs.LF339201 - JP 2014500723-A/146704: Polycomb-Associated Non-Coding RNAs.LF339200 - JP 2014500723-A/146703: Polycomb-Associated Non-Coding RNAs.LF339199 - JP 2014500723-A/146702: Polycomb-Associated Non-Coding RNAs.LF339198 - JP 2014500723-A/146701: Polycomb-Associated Non-Coding RNAs.LF339197 - JP 2014500723-A/146700: Polycomb-Associated Non-Coding RNAs.LF339196 - JP 2014500723-A/146699: Polycomb-Associated Non-Coding RNAs.LF339195 - JP 2014500723-A/146698: Polycomb-Associated Non-Coding RNAs.AK300437 - Homo sapiens cDNA FLJ61596 partial cds, highly similar to Golgin subfamily B member 1.AK296903 - Homo sapiens cDNA FLJ56563 partial cds, highly similar to Golgin subfamily B member 1.LF339194 - JP 2014500723-A/146697: Polycomb-Associated Non-Coding RNAs.LF339193 - JP 2014500723-A/146696: Polycomb-Associated Non-Coding RNAs.LF339192 - JP 2014500723-A/146695: Polycomb-Associated Non-Coding RNAs.LF339191 - JP 2014500723-A/146694: Polycomb-Associated Non-Coding RNAs.AK298986 - Homo sapiens cDNA FLJ54378 partial cds, highly similar to Golgin subfamily B member 1.LF339190 - JP 2014500723-A/146693: Polycomb-Associated Non-Coding RNAs.LF339189 - JP 2014500723-A/146692: Polycomb-Associated Non-Coding RNAs.LF339188 - JP 2014500723-A/146691: Polycomb-Associated Non-Coding RNAs.LF339187 - JP 2014500723-A/146690: Polycomb-Associated Non-Coding RNAs.LF339186 - JP 2014500723-A/146689: Polycomb-Associated Non-Coding RNAs.DQ593569 - Homo sapiens piRNA piR-33681, complete sequence.LF339185 - JP 2014500723-A/146688: Polycomb-Associated Non-Coding RNAs.LF339184 - JP 2014500723-A/146687: Polycomb-Associated Non-Coding RNAs.LF339183 - JP 2014500723-A/146686: Polycomb-Associated Non-Coding RNAs.LF339182 - JP 2014500723-A/146685: Polycomb-Associated Non-Coding RNAs.LF339180 - JP 2014500723-A/146683: Polycomb-Associated Non-Coding RNAs.LF339179 - JP 2014500723-A/146682: Polycomb-Associated Non-Coding RNAs.LF339178 - JP 2014500723-A/146681: Polycomb-Associated Non-Coding RNAs.LF339177 - JP 2014500723-A/146680: Polycomb-Associated Non-Coding RNAs.LF339176 - JP 2014500723-A/146679: Polycomb-Associated Non-Coding RNAs.LF339175 - JP 2014500723-A/146678: Polycomb-Associated Non-Coding RNAs.JD430703 - Sequence 411727 from Patent EP1572962.JD223574 - Sequence 204598 from Patent EP1572962.MA446182 - JP 2018138019-A/18108: Polycomb-Associated Non-Coding RNAs.MA574801 - JP 2018138019-A/146727: Polycomb-Associated Non-Coding RNAs.MA574800 - JP 2018138019-A/146726: Polycomb-Associated Non-Coding RNAs.MA574799 - JP 2018138019-A/146725: Polycomb-Associated Non-Coding RNAs.MA574797 - JP 2018138019-A/146723: Polycomb-Associated Non-Coding RNAs.MA574796 - JP 2018138019-A/146722: Polycomb-Associated Non-Coding RNAs.MA574795 - JP 2018138019-A/146721: Polycomb-Associated Non-Coding RNAs.MA574794 - JP 2018138019-A/146720: Polycomb-Associated Non-Coding RNAs.MA574793 - JP 2018138019-A/146719: Polycomb-Associated Non-Coding RNAs.MA574792 - JP 2018138019-A/146718: Polycomb-Associated Non-Coding RNAs.MA574791 - JP 2018138019-A/146717: Polycomb-Associated Non-Coding RNAs.MA574790 - JP 2018138019-A/146716: Polycomb-Associated Non-Coding RNAs.MA574788 - JP 2018138019-A/146714: Polycomb-Associated Non-Coding RNAs.MA574787 - JP 2018138019-A/146713: Polycomb-Associated Non-Coding RNAs.MA574786 - JP 2018138019-A/146712: Polycomb-Associated Non-Coding RNAs.MA574785 - JP 2018138019-A/146711: Polycomb-Associated Non-Coding RNAs.MA574784 - JP 2018138019-A/146710: Polycomb-Associated Non-Coding RNAs.MA574783 - JP 2018138019-A/146709: Polycomb-Associated Non-Coding RNAs.MA574782 - JP 2018138019-A/146708: Polycomb-Associated Non-Coding RNAs.MA574781 - JP 2018138019-A/146707: Polycomb-Associated Non-Coding RNAs.MA574780 - JP 2018138019-A/146706: Polycomb-Associated Non-Coding RNAs.MA574779 - JP 2018138019-A/146705: Polycomb-Associated Non-Coding RNAs.MA574778 - JP 2018138019-A/146704: Polycomb-Associated Non-Coding RNAs.MA574777 - JP 2018138019-A/146703: Polycomb-Associated Non-Coding RNAs.MA574776 - JP 2018138019-A/146702: Polycomb-Associated Non-Coding RNAs.MA574775 - JP 2018138019-A/146701: Polycomb-Associated Non-Coding RNAs.MA574774 - JP 2018138019-A/146700: Polycomb-Associated Non-Coding RNAs.MA574773 - JP 2018138019-A/146699: Polycomb-Associated Non-Coding RNAs.MA574772 - JP 2018138019-A/146698: Polycomb-Associated Non-Coding RNAs.MA574771 - JP 2018138019-A/146697: Polycomb-Associated Non-Coding RNAs.MA574770 - JP 2018138019-A/146696: Polycomb-Associated Non-Coding RNAs.MA574769 - JP 2018138019-A/146695: Polycomb-Associated Non-Coding RNAs.MA574768 - JP 2018138019-A/146694: Polycomb-Associated Non-Coding RNAs.MA574767 - JP 2018138019-A/146693: Polycomb-Associated Non-Coding RNAs.MA574766 - JP 2018138019-A/146692: Polycomb-Associated Non-Coding RNAs.MA574765 - JP 2018138019-A/146691: Polycomb-Associated Non-Coding RNAs.MA574764 - JP 2018138019-A/146690: Polycomb-Associated Non-Coding RNAs.MA574763 - JP 2018138019-A/146689: Polycomb-Associated Non-Coding RNAs.MA574762 - JP 2018138019-A/146688: Polycomb-Associated Non-Coding RNAs.MA574761 - JP 2018138019-A/146687: Polycomb-Associated Non-Coding RNAs.MA574760 - JP 2018138019-A/146686: Polycomb-Associated Non-Coding RNAs.MA574759 - JP 2018138019-A/146685: Polycomb-Associated Non-Coding RNAs.MA574757 - JP 2018138019-A/146683: Polycomb-Associated Non-Coding RNAs.MA574756 - JP 2018138019-A/146682: Polycomb-Associated Non-Coding RNAs.MA574755 - JP 2018138019-A/146681: Polycomb-Associated Non-Coding RNAs.MA574754 - JP 2018138019-A/146680: Polycomb-Associated Non-Coding RNAs.MA574753 - JP 2018138019-A/146679: Polycomb-Associated Non-Coding RNAs.MA574752 - JP 2018138019-A/146678: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: D3DN92, GOGB1_HUMAN, NM_004487, NP_004478, Q14398, Q14789, uc003eei.4UCSC ID: uc003eei.5RefSeq Accession: NM_004487
Protein: Q14789
(aka GOGB1_HUMAN)
CCDS: CCDS3004.1 , CCDS58847.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_004487.4
exon count:
22 CDS single in 3' UTR:
no
RNA size:
11213
ORF size:
9780 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
19760.00 frame shift in genome:
no
% Coverage:
99.88
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.