Human Gene GOLGB1 (uc003eei.5)
  Description: Homo sapiens golgin B1 (GOLGB1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:121,382,046-121,468,614 Size: 86,569 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr3:121,383,327-121,449,818 Size: 66,492 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:121,382,046-121,468,614)mRNA (may differ from genome)Protein (3259 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GOGB1_HUMAN
DESCRIPTION: RecName: Full=Golgin subfamily B member 1; AltName: Full=372 kDa Golgi complex-associated protein; Short=GCP372; AltName: Full=Giantin; AltName: Full=Macrogolgin;
FUNCTION: May participate in forming intercisternal cross-bridges of the Golgi complex.
SUBUNIT: Homodimer; disulfide-linked. Interacts with PLK3.
INTERACTION: P35080:PFN2; NbExp=2; IntAct=EBI-709973, EBI-473138;
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type I membrane protein.
MISCELLANEOUS: Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GOLGB1
Diseases sorted by gene-association score: pedophilia (9), blue cone monochromacy (8), gastric dilatation (7), gastrointestinal lymphoma (7), paraphilia disorder (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.47 RPKM in Prostate
Total median expression: 692.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.60138-0.417 Picture PostScript Text
3' UTR -411.121281-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026202 - GOLGB1

SCOP Domains:
46966 - Spectrin repeat

ModBase Predicted Comparative 3D Structure on Q14789
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0007030 Golgi organization

Cellular Component:
GO:0000139 Golgi membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005801 cis-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF210605 - JP 2014500723-A/18108: Polycomb-Associated Non-Coding RNAs.
BX537520 - Homo sapiens mRNA; cDNA DKFZp686F09142 (from clone DKFZp686F09142).
AB371588 - Homo sapiens GOLGB1 mRNA for golgin B1, splicing variant, complete cds, clone: HP08164-ARiS161G17c.
AB593126 - Homo sapiens GOLGB1 mRNA for Golgin subfamily B member 1, complete cds, clone: HP08164-RBdS040G23.
LF339224 - JP 2014500723-A/146727: Polycomb-Associated Non-Coding RNAs.
D25542 - Homo sapiens mRNA for golgi antigen gcp372, complete cds.
X75304 - H.sapiens giantin mRNA.
JD074170 - Sequence 55194 from Patent EP1572962.
AK094551 - Homo sapiens cDNA FLJ37232 fis, clone BRAMY2001114.
JD202165 - Sequence 183189 from Patent EP1572962.
JD181984 - Sequence 163008 from Patent EP1572962.
JD122927 - Sequence 103951 from Patent EP1572962.
JD563111 - Sequence 544135 from Patent EP1572962.
JD375872 - Sequence 356896 from Patent EP1572962.
LF339223 - JP 2014500723-A/146726: Polycomb-Associated Non-Coding RNAs.
LF339222 - JP 2014500723-A/146725: Polycomb-Associated Non-Coding RNAs.
LF339220 - JP 2014500723-A/146723: Polycomb-Associated Non-Coding RNAs.
LF339219 - JP 2014500723-A/146722: Polycomb-Associated Non-Coding RNAs.
LF339218 - JP 2014500723-A/146721: Polycomb-Associated Non-Coding RNAs.
LF339217 - JP 2014500723-A/146720: Polycomb-Associated Non-Coding RNAs.
LF339216 - JP 2014500723-A/146719: Polycomb-Associated Non-Coding RNAs.
LF339215 - JP 2014500723-A/146718: Polycomb-Associated Non-Coding RNAs.
LF339214 - JP 2014500723-A/146717: Polycomb-Associated Non-Coding RNAs.
LF339213 - JP 2014500723-A/146716: Polycomb-Associated Non-Coding RNAs.
BC057227 - Homo sapiens golgin B1, golgi integral membrane protein, mRNA (cDNA clone IMAGE:4702419), partial cds.
LF339211 - JP 2014500723-A/146714: Polycomb-Associated Non-Coding RNAs.
LF339210 - JP 2014500723-A/146713: Polycomb-Associated Non-Coding RNAs.
LF339209 - JP 2014500723-A/146712: Polycomb-Associated Non-Coding RNAs.
LF339208 - JP 2014500723-A/146711: Polycomb-Associated Non-Coding RNAs.
LF339207 - JP 2014500723-A/146710: Polycomb-Associated Non-Coding RNAs.
LF339206 - JP 2014500723-A/146709: Polycomb-Associated Non-Coding RNAs.
LF339205 - JP 2014500723-A/146708: Polycomb-Associated Non-Coding RNAs.
LF339204 - JP 2014500723-A/146707: Polycomb-Associated Non-Coding RNAs.
LF339203 - JP 2014500723-A/146706: Polycomb-Associated Non-Coding RNAs.
BC065301 - Homo sapiens golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1, mRNA (cDNA clone IMAGE:6157315).
LF339202 - JP 2014500723-A/146705: Polycomb-Associated Non-Coding RNAs.
LF339201 - JP 2014500723-A/146704: Polycomb-Associated Non-Coding RNAs.
LF339200 - JP 2014500723-A/146703: Polycomb-Associated Non-Coding RNAs.
LF339199 - JP 2014500723-A/146702: Polycomb-Associated Non-Coding RNAs.
LF339198 - JP 2014500723-A/146701: Polycomb-Associated Non-Coding RNAs.
LF339197 - JP 2014500723-A/146700: Polycomb-Associated Non-Coding RNAs.
LF339196 - JP 2014500723-A/146699: Polycomb-Associated Non-Coding RNAs.
LF339195 - JP 2014500723-A/146698: Polycomb-Associated Non-Coding RNAs.
AK300437 - Homo sapiens cDNA FLJ61596 partial cds, highly similar to Golgin subfamily B member 1.
AK296903 - Homo sapiens cDNA FLJ56563 partial cds, highly similar to Golgin subfamily B member 1.
LF339194 - JP 2014500723-A/146697: Polycomb-Associated Non-Coding RNAs.
LF339193 - JP 2014500723-A/146696: Polycomb-Associated Non-Coding RNAs.
LF339192 - JP 2014500723-A/146695: Polycomb-Associated Non-Coding RNAs.
LF339191 - JP 2014500723-A/146694: Polycomb-Associated Non-Coding RNAs.
AK298986 - Homo sapiens cDNA FLJ54378 partial cds, highly similar to Golgin subfamily B member 1.
LF339190 - JP 2014500723-A/146693: Polycomb-Associated Non-Coding RNAs.
LF339189 - JP 2014500723-A/146692: Polycomb-Associated Non-Coding RNAs.
LF339188 - JP 2014500723-A/146691: Polycomb-Associated Non-Coding RNAs.
LF339187 - JP 2014500723-A/146690: Polycomb-Associated Non-Coding RNAs.
LF339186 - JP 2014500723-A/146689: Polycomb-Associated Non-Coding RNAs.
DQ593569 - Homo sapiens piRNA piR-33681, complete sequence.
LF339185 - JP 2014500723-A/146688: Polycomb-Associated Non-Coding RNAs.
LF339184 - JP 2014500723-A/146687: Polycomb-Associated Non-Coding RNAs.
LF339183 - JP 2014500723-A/146686: Polycomb-Associated Non-Coding RNAs.
LF339182 - JP 2014500723-A/146685: Polycomb-Associated Non-Coding RNAs.
LF339180 - JP 2014500723-A/146683: Polycomb-Associated Non-Coding RNAs.
LF339179 - JP 2014500723-A/146682: Polycomb-Associated Non-Coding RNAs.
LF339178 - JP 2014500723-A/146681: Polycomb-Associated Non-Coding RNAs.
LF339177 - JP 2014500723-A/146680: Polycomb-Associated Non-Coding RNAs.
LF339176 - JP 2014500723-A/146679: Polycomb-Associated Non-Coding RNAs.
LF339175 - JP 2014500723-A/146678: Polycomb-Associated Non-Coding RNAs.
JD430703 - Sequence 411727 from Patent EP1572962.
JD223574 - Sequence 204598 from Patent EP1572962.
MA446182 - JP 2018138019-A/18108: Polycomb-Associated Non-Coding RNAs.
MA574801 - JP 2018138019-A/146727: Polycomb-Associated Non-Coding RNAs.
MA574800 - JP 2018138019-A/146726: Polycomb-Associated Non-Coding RNAs.
MA574799 - JP 2018138019-A/146725: Polycomb-Associated Non-Coding RNAs.
MA574797 - JP 2018138019-A/146723: Polycomb-Associated Non-Coding RNAs.
MA574796 - JP 2018138019-A/146722: Polycomb-Associated Non-Coding RNAs.
MA574795 - JP 2018138019-A/146721: Polycomb-Associated Non-Coding RNAs.
MA574794 - JP 2018138019-A/146720: Polycomb-Associated Non-Coding RNAs.
MA574793 - JP 2018138019-A/146719: Polycomb-Associated Non-Coding RNAs.
MA574792 - JP 2018138019-A/146718: Polycomb-Associated Non-Coding RNAs.
MA574791 - JP 2018138019-A/146717: Polycomb-Associated Non-Coding RNAs.
MA574790 - JP 2018138019-A/146716: Polycomb-Associated Non-Coding RNAs.
MA574788 - JP 2018138019-A/146714: Polycomb-Associated Non-Coding RNAs.
MA574787 - JP 2018138019-A/146713: Polycomb-Associated Non-Coding RNAs.
MA574786 - JP 2018138019-A/146712: Polycomb-Associated Non-Coding RNAs.
MA574785 - JP 2018138019-A/146711: Polycomb-Associated Non-Coding RNAs.
MA574784 - JP 2018138019-A/146710: Polycomb-Associated Non-Coding RNAs.
MA574783 - JP 2018138019-A/146709: Polycomb-Associated Non-Coding RNAs.
MA574782 - JP 2018138019-A/146708: Polycomb-Associated Non-Coding RNAs.
MA574781 - JP 2018138019-A/146707: Polycomb-Associated Non-Coding RNAs.
MA574780 - JP 2018138019-A/146706: Polycomb-Associated Non-Coding RNAs.
MA574779 - JP 2018138019-A/146705: Polycomb-Associated Non-Coding RNAs.
MA574778 - JP 2018138019-A/146704: Polycomb-Associated Non-Coding RNAs.
MA574777 - JP 2018138019-A/146703: Polycomb-Associated Non-Coding RNAs.
MA574776 - JP 2018138019-A/146702: Polycomb-Associated Non-Coding RNAs.
MA574775 - JP 2018138019-A/146701: Polycomb-Associated Non-Coding RNAs.
MA574774 - JP 2018138019-A/146700: Polycomb-Associated Non-Coding RNAs.
MA574773 - JP 2018138019-A/146699: Polycomb-Associated Non-Coding RNAs.
MA574772 - JP 2018138019-A/146698: Polycomb-Associated Non-Coding RNAs.
MA574771 - JP 2018138019-A/146697: Polycomb-Associated Non-Coding RNAs.
MA574770 - JP 2018138019-A/146696: Polycomb-Associated Non-Coding RNAs.
MA574769 - JP 2018138019-A/146695: Polycomb-Associated Non-Coding RNAs.
MA574768 - JP 2018138019-A/146694: Polycomb-Associated Non-Coding RNAs.
MA574767 - JP 2018138019-A/146693: Polycomb-Associated Non-Coding RNAs.
MA574766 - JP 2018138019-A/146692: Polycomb-Associated Non-Coding RNAs.
MA574765 - JP 2018138019-A/146691: Polycomb-Associated Non-Coding RNAs.
MA574764 - JP 2018138019-A/146690: Polycomb-Associated Non-Coding RNAs.
MA574763 - JP 2018138019-A/146689: Polycomb-Associated Non-Coding RNAs.
MA574762 - JP 2018138019-A/146688: Polycomb-Associated Non-Coding RNAs.
MA574761 - JP 2018138019-A/146687: Polycomb-Associated Non-Coding RNAs.
MA574760 - JP 2018138019-A/146686: Polycomb-Associated Non-Coding RNAs.
MA574759 - JP 2018138019-A/146685: Polycomb-Associated Non-Coding RNAs.
MA574757 - JP 2018138019-A/146683: Polycomb-Associated Non-Coding RNAs.
MA574756 - JP 2018138019-A/146682: Polycomb-Associated Non-Coding RNAs.
MA574755 - JP 2018138019-A/146681: Polycomb-Associated Non-Coding RNAs.
MA574754 - JP 2018138019-A/146680: Polycomb-Associated Non-Coding RNAs.
MA574753 - JP 2018138019-A/146679: Polycomb-Associated Non-Coding RNAs.
MA574752 - JP 2018138019-A/146678: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14789 (Reactome details) participates in the following event(s):

R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex
R-HSA-8874979 ACBD3 binds GOLGB1
R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-421837 Clathrin derived vesicle budding
R-HSA-199991 Membrane Trafficking
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-5653656 Vesicle-mediated transport
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: D3DN92, GOGB1_HUMAN, NM_004487, NP_004478, Q14398, Q14789, uc003eei.4
UCSC ID: uc003eei.5
RefSeq Accession: NM_004487
Protein: Q14789 (aka GOGB1_HUMAN)
CCDS: CCDS3004.1, CCDS58847.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004487.4
exon count: 22CDS single in 3' UTR: no RNA size: 11213
ORF size: 9780CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 19760.00frame shift in genome: no % Coverage: 99.88
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.