Description: Homo sapiens Zic family member 4 (ZIC4), transcript variant 3, mRNA. RefSeq Summary (NM_032153): This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]. Transcript (Including UTRs) Position: hg19 chr3:147,103,835-147,124,596 Size: 20,762 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr3:147,106,646-147,120,584 Size: 13,939 Coding Exon Count: 4
ID:ZIC4_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein ZIC 4; AltName: Full=Zinc finger protein of the cerebellum 4; FUNCTION: Binds to DNA (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers. CAUTION: It is uncertain whether Met-1 is the initiator. SEQUENCE CAUTION: Sequence=AAH29507.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 229; Sequence=AAK06845.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N9L1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter
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