Description: Homo sapiens arginine/serine-rich coiled-coil 1 (RSRC1), transcript variant 2, mRNA. RefSeq Summary (NM_016625): This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg19 chr3:157,827,841-158,262,624 Size: 434,784 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr3:157,839,894-158,262,064 Size: 422,171 Coding Exon Count: 9
ID:RSRC1_HUMAN DESCRIPTION: RecName: Full=Serine/Arginine-related protein 53; Short=SRrp53; AltName: Full=Arginine/serine-rich coiled-coil protein 1; FUNCTION: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. SUBUNIT: Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1. SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus speckle (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and cytoplasm (By similarity). PTM: Phosphorylated (By similarity). SEQUENCE CAUTION: Sequence=AAF64267.1; Type=Frameshift; Positions=159, 166, 174, 178;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q96IZ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
