Human Gene YEATS2 (uc003flz.3)
  Description: Homo sapiens YEATS domain containing 2 (YEATS2), mRNA.
RefSeq Summary (NM_018023): The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017].
Transcript (Including UTRs)
   Position: hg19 chr3:183,493,703-183,511,271 Size: 17,569 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr3:183,503,940-183,510,908 Size: 6,969 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:183,493,703-183,511,271)mRNA (may differ from genome)Protein (112 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIPubMed
UniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): YEATS2
CDC HuGE Published Literature: YEATS2

-  MalaCards Disease Associations
  MalaCards Gene Search: YEATS2
Diseases sorted by gene-association score: enchondromatosis, multiple, ollier type (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.57 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 388.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -133.20395-0.337 Picture PostScript Text
3' UTR -94.61363-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005033 - YEATS

ModBase Predicted Comparative 3D Structure on Q8N5H6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AB033023 - Homo sapiens KIAA1197 mRNA for KIAA1197 protein.
BC150273 - Homo sapiens YEATS domain containing 2, mRNA (cDNA clone MGC:166875 IMAGE:9007245), complete cds.
AB384135 - Synthetic construct DNA, clone: pF1KSDA1197, Homo sapiens YEATS2 gene for YEATS domain-containing protein 2, complete cds, without stop codon, in Flexi system.
KJ899171 - Synthetic construct Homo sapiens clone ccsbBroadEn_08565 YEATS2 gene, encodes complete protein.
BC043393 - Homo sapiens YEATS domain containing 2, mRNA (cDNA clone IMAGE:5498791).
BC082270 - Homo sapiens YEATS domain containing 2, mRNA (cDNA clone IMAGE:3960342), partial cds.
BC032368 - Homo sapiens YEATS domain containing 2, mRNA (cDNA clone IMAGE:4473752), partial cds.
AK001063 - Homo sapiens cDNA FLJ10201 fis, clone HEMBA1004923.

-  Other Names for This Gene
  Alternate Gene Symbols: BC032368, Q8N5H6, Q8N5H6_HUMAN
UCSC ID: uc003flz.3
RefSeq Accession: NM_018023
Protein: Q8N5H6

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC032368.1
exon count: 5CDS single in 3' UTR: no RNA size: 967
ORF size: 339CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 758.00frame shift in genome: no % Coverage: 97.41
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.