Human Gene MAP3K13 (uc003fph.4)
  Description: Homo sapiens mitogen-activated protein kinase kinase kinase 13 (MAP3K13), transcript variant 2, mRNA.
RefSeq Summary (NM_001242314): The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr3:185,046,683-185,169,322 Size: 122,640 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr3:185,161,270-185,169,225 Size: 7,956 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:185,046,683-185,169,322)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: H7C459_HUMAN
DESCRIPTION: SubName: Full=Mitogen-activated protein kinase kinase kinase 13; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MAP3K13
CDC HuGE Published Literature: MAP3K13
Positive Disease Associations: Diabetes Mellitus, Type 2
Related Studies:
  1. Diabetes Mellitus, Type 2
    Laura J Scott et al. Science (New York, N.Y.) 2007, A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants., Science (New York, N.Y.). [PubMed 17463248]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.12 RPKM in Pituitary
Total median expression: 174.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -249.39739-0.337 Picture PostScript Text
3' UTR -14.6097-0.151 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on H7C459
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation


-  Descriptions from all associated GenBank mRNAs
  AK297646 - Homo sapiens cDNA FLJ58266 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25).
AK312714 - Homo sapiens cDNA, FLJ93116, Homo sapiens mitogen-activated protein kinase kinase kinase 13 (MAP3K13), mRNA.
AK302951 - Homo sapiens cDNA FLJ58309 complete cds, highly similar to Mitogen-activated protein kinase kinasekinase 13 (EC 2.7.11.25).
BC031677 - Homo sapiens mitogen-activated protein kinase kinase kinase 13, mRNA (cDNA clone IMAGE:5167124), complete cds.
AK296961 - Homo sapiens cDNA FLJ56375 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25).
AB001872 - Homo sapiens mRNA for leucine zipper bearing kinase, complete cds.
BC111726 - Homo sapiens mitogen-activated protein kinase kinase kinase 13, mRNA (cDNA clone MGC:133196 IMAGE:40028559), complete cds.
JD565432 - Sequence 546456 from Patent EP1572962.
JD279486 - Sequence 260510 from Patent EP1572962.
Z25428 - H.sapiens protein-serine/threonine kinase gene, complete CDS.
KJ901950 - Synthetic construct Homo sapiens clone ccsbBroadEn_11344 MAP3K13 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_mapkPathway - MAPKinase Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: BC031677, H7C459, H7C459_HUMAN
UCSC ID: uc003fph.4
RefSeq Accession: NM_001242314
Protein: H7C459

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC031677.1
exon count: 7CDS single in 3' UTR: no RNA size: 1506
ORF size: 624CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 964.00frame shift in genome: no % Coverage: 95.68
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 139# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.