Description: Homo sapiens mitogen-activated protein kinase kinase kinase 13 (MAP3K13), transcript variant 2, mRNA. RefSeq Summary (NM_001242314): The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr3:185,046,683-185,169,322 Size: 122,640 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr3:185,161,270-185,169,225 Size: 7,956 Coding Exon Count: 4
ID:H7C459_HUMAN DESCRIPTION: SubName: Full=Mitogen-activated protein kinase kinase kinase 13; Flags: Fragment; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MAP3K13 CDC HuGE Published Literature: MAP3K13 Positive Disease Associations: Diabetes Mellitus, Type 2 Related Studies:
Diabetes Mellitus, Type 2 Laura J Scott et al. Science (New York, N.Y.) 2007, A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants., Science (New York, N.Y.).
[PubMed 17463248]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on H7C459
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.