Human Gene ZNF721 (uc003gag.4)
  Description: Homo sapiens zinc finger protein 721 (ZNF721), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:433,773-492,960 Size: 59,188 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr4:435,484-466,397 Size: 30,914 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:433,773-492,960)mRNA (may differ from genome)Protein (923 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIPubMed
ReactomeUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.57 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 238.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.30209-0.379 Picture PostScript Text
3' UTR -425.911711-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger
PF16622 - zinc-finger C2H2-type

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q8TF20-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC036795 - Homo sapiens, clone IMAGE:5590487, mRNA.
AK024359 - Homo sapiens cDNA FLJ14297 fis, clone PLACE1008941.
BC098116 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024290).
BC098259 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024295).
BC098291 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024296), containing frame-shift errors.
BC099730 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024298).
BC105084 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:8144087).
BC112069 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:8327537).
BC143677 - Homo sapiens cDNA clone IMAGE:9052191.
AK303674 - Homo sapiens cDNA FLJ57767 complete cds, moderately similar to Zinc finger protein 141.
AL834155 - Homo sapiens mRNA; cDNA DKFZp761O0611 (from clone DKFZp761O0611).
AK095689 - Homo sapiens cDNA FLJ38370 fis, clone FEBRA2001869, weakly similar to ZINC FINGER PROTEIN 44.
AB075862 - Homo sapiens mRNA for KIAA1982 protein.
AK128499 - Homo sapiens cDNA FLJ46649 fis, clone TRACH3004424, moderately similar to Zinc finger protein 91.
AK092362 - Homo sapiens cDNA FLJ35043 fis, clone OCBBF2017536, weakly similar to Homo sapiens C2H2 (Kruppel-type) zinc finger protein mRNA.
AX747501 - Sequence 1026 from Patent EP1308459.
AK095558 - Homo sapiens cDNA FLJ38239 fis, clone FCBBF2005909, weakly similar to ZINC FINGER PROTEIN 44.
AK127067 - Homo sapiens cDNA FLJ45124 fis, clone BRAWH3036334, moderately similar to Zinc finger protein 91.
JD179301 - Sequence 160325 from Patent EP1572962.
JD481205 - Sequence 462229 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD314873 - Sequence 295897 from Patent EP1572962.
JD314874 - Sequence 295898 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD314884 - Sequence 295908 from Patent EP1572962.
JD314873 - Sequence 295897 from Patent EP1572962.
JD314874 - Sequence 295898 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD442012 - Sequence 423036 from Patent EP1572962.
JD314884 - Sequence 295908 from Patent EP1572962.
JD066994 - Sequence 48018 from Patent EP1572962.
JD330516 - Sequence 311540 from Patent EP1572962.
JD330513 - Sequence 311537 from Patent EP1572962.
JD330514 - Sequence 311538 from Patent EP1572962.
JD330515 - Sequence 311539 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314898 - Sequence 295922 from Patent EP1572962.
JD314899 - Sequence 295923 from Patent EP1572962.
JD314900 - Sequence 295924 from Patent EP1572962.
BC060316 - Homo sapiens cDNA clone IMAGE:3882186, partial cds.
BC065035 - Homo sapiens cDNA clone IMAGE:6171511, partial cds.
JD435224 - Sequence 416248 from Patent EP1572962.
JD102297 - Sequence 83321 from Patent EP1572962.
JD392731 - Sequence 373755 from Patent EP1572962.
BC040413 - Homo sapiens, clone IMAGE:5186165, mRNA.
JD516749 - Sequence 497773 from Patent EP1572962.
AK021514 - Homo sapiens cDNA FLJ11452 fis, clone HEMBA1001435.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TF20 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1982, NM_133474, NP_597731, Q8TF20-2, uc003gag.3
UCSC ID: uc003gag.4
RefSeq Accession: NM_133474
Protein: Q8TF20-2, splice isoform of Q8TF20 CCDS: CCDS46991.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_133474.3
exon count: 3CDS single in 3' UTR: no RNA size: 4696
ORF size: 2772CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5672.00frame shift in genome: no % Coverage: 99.91
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 4359# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.