Human Gene POLR2B (uc003hcm.1)
  Description: Homo sapiens polymerase (RNA) II (DNA directed) polypeptide B, 140kDa (POLR2B), mRNA.
RefSeq Summary (NM_000938): This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Transcript (Including UTRs)
   Position: hg19 chr4:57,875,725-57,897,334 Size: 21,610 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr4:57,876,644-57,897,154 Size: 20,511 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:57,875,725-57,897,334)mRNA (may differ from genome)Protein (667 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RPB2_HUMAN
DESCRIPTION: RecName: Full=DNA-directed RNA polymerase II subunit RPB2; EC=2.7.7.6; AltName: Full=DNA-directed RNA polymerase II 140 kDa polypeptide; AltName: Full=DNA-directed RNA polymerase II subunit B; AltName: Full=RNA polymerase II subunit 2; AltName: Full=RNA polymerase II subunit B2;
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
SUBUNIT: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with WDR82. Interacts with MEN1.
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two- step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).
SIMILARITY: Belongs to the RNA polymerase beta chain family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): POLR2B
CDC HuGE Published Literature: POLR2B
Positive Disease Associations: head and neck cancer lung cancer
Related Studies:
  1. head and neck cancer lung cancer
    Michiels, S. et al. 2007, Polymorphism discovery in 62 DNA repair genes and haplotype-associations with risks for lung, and head and neck cancers, Carcinogenesis 2007. [PubMed 17494052]

-  MalaCards Disease Associations
  MalaCards Gene Search: POLR2B
Diseases sorted by gene-association score: eumycotic mycetoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.79 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1113.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -230.50919-0.251 Picture PostScript Text
3' UTR -32.00180-0.178 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015712 - DNA-dir_RNA_pol_su2
IPR007120 - DNA-dir_RNA_pol_su2_6
IPR007121 - RNA_pol_bsu_CS
IPR007644 - RNA_pol_bsu_protrusion
IPR007642 - RNA_pol_Rpb2_2
IPR007645 - RNA_pol_Rpb2_3
IPR007646 - RNA_pol_Rpb2_4
IPR007647 - RNA_pol_Rpb2_5
IPR007641 - RNA_pol_Rpb2_7
IPR014724 - RNA_pol_RPB2_OB-fold

Pfam Domains:
PF00562 - RNA polymerase Rpb2, domain 6
PF04560 - RNA polymerase Rpb2, domain 7
PF04565 - RNA polymerase Rpb2, domain 3
PF04566 - RNA polymerase Rpb2, domain 4
PF04567 - RNA polymerase Rpb2, domain 5

SCOP Domains:
64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase

ModBase Predicted Comparative 3D Structure on P30876
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0046872 metal ion binding
GO:0001055 RNA polymerase II activity

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016070 RNA metabolic process
GO:0042795 snRNA transcription from RNA polymerase II promoter
GO:0060964 regulation of gene silencing by miRNA

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0016020 membrane
GO:0000784 nuclear chromosome, telomeric region


-  Descriptions from all associated GenBank mRNAs
  LF213719 - JP 2014500723-A/21222: Polycomb-Associated Non-Coding RNAs.
MA449296 - JP 2018138019-A/21222: Polycomb-Associated Non-Coding RNAs.
LP895484 - Sequence 348 from Patent EP3253886.
AK294901 - Homo sapiens cDNA FLJ61678 complete cds, highly similar to DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6).
AK299090 - Homo sapiens cDNA FLJ59391 complete cds, highly similar to DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6).
AK295132 - Homo sapiens cDNA FLJ52411 complete cds, highly similar to DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6).
BC023503 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide B, 140kDa, mRNA (cDNA clone MGC:1677 IMAGE:3346389), complete cds.
AK289823 - Homo sapiens cDNA FLJ75210 complete cds, highly similar to H.sapiens mRNA for RNA polymerase II 140 kDa subunit.
X63563 - H.sapiens mRNA for RNA polymerase II 140 kDa subunit.
AB384836 - Synthetic construct DNA, clone: pF1KB3683, Homo sapiens POLR2B gene for DNA-directed RNA polymerase II subunit RPB2, complete cds, without stop codon, in Flexi system.
KJ905276 - Synthetic construct Homo sapiens clone ccsbBroadEn_14773 POLR2B-like gene, encodes complete protein.
BC046499 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide B, 140kDa, mRNA (cDNA clone IMAGE:4822320), with apparent retained intron.
AF055028 - Homo sapiens clone 24498 RNA polymerase II 140 kDa subunit mRNA, partial cds.
AK098271 - Homo sapiens cDNA FLJ40952 fis, clone UTERU2010164.
DL492509 - Novel nucleic acids.
DL490978 - Novel nucleic acids.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism
hsa00240 - Pyrimidine metabolism
hsa01100 - Metabolic pathways
hsa03020 - RNA polymerase
hsa05016 - Huntington's disease

Reactome (by CSHL, EBI, and GO)

Protein P30876 (Reactome details) participates in the following event(s):

R-HSA-113429 Elongating transcript encounters a lesion in the template
R-HSA-5578742 AGO1,2:small RNA complexes interact with chromatin
R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)
R-HSA-112395 Abortive termination of elongation after arrest
R-HSA-167459 Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)
R-HSA-167481 Abortive termination of HIV-1 elongation after arrest
R-HSA-6781840 ERCC6 binds stalled RNA Pol II
R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
R-HSA-73946 Abortive initiation
R-HSA-75856 Abortive Initiation Before Second Transition
R-HSA-75891 Abortive Initiation After Second Transition
R-HSA-167468 Abortive HIV-1 Initiation After Second Transition
R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition
R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond
R-HSA-113407 DSIF complex binds to RNA Pol II (hypophosphorylated)
R-HSA-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein
R-HSA-167083 DSIF complex binds to RNA Pol II (hypophosphorylated)
R-HSA-167072 Hypophosphorylation of RNA Pol II CTD by FCP1P protein
R-HSA-9012315 ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene
R-HSA-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site
R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER
R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER
R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain
R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
R-HSA-112379 Recruitment of elongation factors to form elongation complex
R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates
R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
R-HSA-112385 Addition of nucleotides leads to transcript elongation
R-HSA-112392 Resumption of elongation after recovery from pausing
R-HSA-113413 TFIIS-mediated recovery of elongation from arrest
R-HSA-112396 Separation of elongating transcript from template
R-HSA-167150 Resumption of elongation of HIV-1 transcript after recovery from pausing
R-HSA-167076 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex
R-HSA-167084 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest
R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing
R-HSA-167148 TFIIS-mediated recovery of elongation from arrest
R-HSA-167090 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
R-HSA-170706 Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
R-HSA-167191 Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
R-HSA-167192 Pol II elongation complex moves on the HIV-1 template as transcript elongates
R-HSA-167181 Addition of nucleotides leads to HIV-1 transcript elongation
R-HSA-167197 Separation of elongating HIV-1 transcript from template
R-HSA-170704 Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
R-HSA-167196 Recruitment of elongation factors to form HIV-1 elongation complex
R-HSA-6781833 ERCC8 (CSA) binds stalled RNA Pol II
R-HSA-72103 Formation of pre-mRNPs
R-HSA-75080 Formation of AT-AC A complex
R-HSA-72095 Internal Methylation of mRNA
R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript
R-HSA-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
R-HSA-111264 Addition of nucleotides between position +11 and +30
R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released
R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
R-HSA-75095 Binding of TFIIE to the growing preinitiation complex
R-HSA-75861 NTP Binds Active Site of RNA Polymerase II
R-HSA-75862 Fall Back to Closed Pre-initiation Complex
R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition
R-HSA-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
R-HSA-77071 Phosphorylation (Ser5) of RNA pol II CTD
R-HSA-167117 Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released
R-HSA-167098 Phosphorylation (Ser5) of RNA pol II CTD
R-HSA-167111 Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex
R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
R-HSA-167115 Addition of nucleotides between position +11 and +30 on HIV-1 transcript
R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
R-HSA-167484 Fall Back to Closed Pre-initiation Complex
R-HSA-167097 HIV Promoter Opening: First Transition
R-HSA-6803523 PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
R-HSA-6803527 ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression
R-HSA-113402 Formation of DSIF:NELF:early elongation complex
R-HSA-167085 Formation of DSIF:NELF:HIV-1 early elongation complex
R-HSA-77068 Activation of GT
R-HSA-77069 RNA Polymerase II CTD (phosphorylated) binds to CE
R-HSA-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
R-HSA-77077 Capping complex formation
R-HSA-156661 Formation of Exon Junction Complex
R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage
R-HSA-77095 Recognition and binding of the mRNA cap by the cap-binding complex
R-HSA-77090 Methylation of GMP-cap by RNA Methyltransferase
R-HSA-167089 Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex
R-HSA-167133 Activation of GT
R-HSA-167128 RNA Polymerase II CTD (phosphorylated) binds to CE
R-HSA-167153 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA
R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes
R-HSA-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
R-HSA-72107 Formation of the Spliceosomal E complex
R-HSA-72139 Formation of the active Spliceosomal C (B*) complex
R-HSA-72124 Formation of the Spliceosomal A Complex
R-HSA-72127 Formation of the Spliceosomal B Complex
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex
R-HSA-75081 Formation of AT-AC B Complex
R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage
R-HSA-75079 Formation of AT-AC C complex
R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation
R-HSA-109639 Formation of the closed pre-initiation complex
R-HSA-113409 Abortive termination of early transcription elongation by DSIF:NELF
R-HSA-167087 Limited elongation of the HIV-1 transcript
R-HSA-167478 Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
R-HSA-167147 Separation of abortive HIV-1 transcript from template
R-HSA-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
R-HSA-77081 Formation of the CE:GMP intermediate complex
R-HSA-77085 Dissociation of transcript with 5'-GMP from GT
R-HSA-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
R-HSA-6782004 Assembly of the pre-incision complex in TC-NER
R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6
R-HSA-6782131 RNA Pol II backtracking in TC-NER
R-HSA-6782138 ERCC5 and RPA bind TC-NER site
R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167161 HIV Transcription Initiation
R-HSA-211000 Gene Silencing by RNA
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167172 Transcription of the HIV genome
R-HSA-74160 Gene expression (Transcription)
R-HSA-73894 DNA Repair
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-167169 HIV Transcription Elongation
R-HSA-8939211 ESR-mediated signaling
R-HSA-72086 mRNA Capping
R-HSA-72172 mRNA Splicing
R-HSA-1266738 Developmental Biology
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-8953854 Metabolism of RNA
R-HSA-5654738 Signaling by FGFR2
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-162587 HIV Life Cycle
R-HSA-190236 Signaling by FGFR
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-162582 Signal Transduction
R-HSA-212436 Generic Transcription Pathway
R-HSA-162906 HIV Infection
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5663205 Infectious disease
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1A8, BC046499, NM_000938, NP_000929, P30876, Q8IZ61, RPB2_HUMAN
UCSC ID: uc003hcm.1
RefSeq Accession: NM_000938
Protein: P30876 (aka RPB2_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC046499.1
exon count: 15CDS single in 3' UTR: no RNA size: 3174
ORF size: 2004CDS single in intron: no Alignment % ID: 99.90
txCdsPredict score: 3590.00frame shift in genome: no % Coverage: 97.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 802# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.