ID:SAS10_HUMAN DESCRIPTION: RecName: Full=Something about silencing protein 10; AltName: Full=Charged amino acid-rich leucine zipper 1; Short=CRL1; AltName: Full=Disrupter of silencing SAS10; AltName: Full=UTP3 homolog; FUNCTION: Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the SAS10 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQZ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF271212 - Homo sapiens disrupter of silencing SAS10 (SAS10) mRNA, complete cds. AK026909 - Homo sapiens cDNA: FLJ23256 fis, clone COL05534. BC004546 - Homo sapiens UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae), mRNA (cDNA clone MGC:11290 IMAGE:3946633), complete cds. AL136590 - Homo sapiens mRNA; cDNA DKFZp761F222 (from clone DKFZp761F222). AB463337 - Synthetic construct DNA, clone: pF1KB8692, Homo sapiens UTP3 gene for UTP3, small subunit (SSU) processome component, homolog, without stop codon, in Flexi system. AM392862 - Synthetic construct Homo sapiens clone IMAGE:100001994 for hypothetical protein (SAS10 gene). AM393072 - Synthetic construct Homo sapiens clone IMAGE:100001988 for hypothetical protein (SAS10 gene). AM393229 - Synthetic construct Homo sapiens clone IMAGE:100001722 for hypothetical protein (SAS10 gene). DQ892999 - Synthetic construct clone IMAGE:100005629; FLH191526.01X; RZPDo839E0377D disrupter of silencing 10 (SAS10) gene, encodes complete protein. EU176750 - Synthetic construct Homo sapiens clone IMAGE:100011529; FLH191525.01L; RZPDo839B12255D disrupter of silencing 10 (SAS10) gene, encodes complete protein. CU678762 - Synthetic construct Homo sapiens gateway clone IMAGE:100020291 5' read UTP3 mRNA. KJ894380 - Synthetic construct Homo sapiens clone ccsbBroadEn_03774 UTP3 gene, encodes complete protein. CR533544 - Homo sapiens full open reading frame cDNA clone RZPDo834F0819D for gene SAS10, disrupter of silencing 10; complete cds, incl. stopcodon. JD296159 - Sequence 277183 from Patent EP1572962. JD092600 - Sequence 73624 from Patent EP1572962. JD549390 - Sequence 530414 from Patent EP1572962. MP014830 - Sequence 33 from Patent WO2019016252.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NQZ2 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA
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