Description: Homo sapiens platelet factor 4 (PF4), mRNA. RefSeq Summary (NM_002619): This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]. Transcript (Including UTRs) Position: hg19 chr4:74,846,542-74,847,841 Size: 1,300 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr4:74,846,921-74,847,670 Size: 750 Coding Exon Count: 3
ID:PLF4_HUMAN DESCRIPTION: RecName: Full=Platelet factor 4; Short=PF-4; AltName: Full=C-X-C motif chemokine 4; AltName: Full=Iroplact; AltName: Full=Oncostatin-A; Contains: RecName: Full=Platelet factor 4, short form; Flags: Precursor; FUNCTION: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Secreted. PTM: Binds non-covalently to a proteoglycan molecule. MASS SPECTROMETRY: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496; MASS SPECTROMETRY: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496; SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL4 entry; URL="http://en.wikipedia.org/wiki/CXCL4";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02776
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.