Description: Homo sapiens protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), transcript variant 1, mRNA. RefSeq Summary (NM_080683): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]. Transcript (Including UTRs) Position: hg19 chr4:87,515,468-87,736,328 Size: 220,861 Total Exon Count: 48 Strand: + Coding Region Position: hg19 chr4:87,556,410-87,735,704 Size: 179,295 Coding Exon Count: 47
ID:PTN13_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein phosphatase non-receptor type 13; EC=3.1.3.48; AltName: Full=Fas-associated protein-tyrosine phosphatase 1; Short=FAP-1; AltName: Full=PTP-BAS; AltName: Full=Protein-tyrosine phosphatase 1E; Short=PTP-E1; Short=hPTPE1; AltName: Full=Protein-tyrosine phosphatase PTPL1; FUNCTION: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus). INTERACTION: Q9BUL8:PDCD10; NbExp=3; IntAct=EBI-355227, EBI-740195; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. TISSUE SPECIFICITY: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 1 KIND domain. SIMILARITY: Contains 5 PDZ (DHR) domains. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. SEQUENCE CAUTION: Sequence=AAH39610.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTPN13ID41912ch4q21.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00102 - Protein-tyrosine phosphatase PF00373 - FERM central domain PF00595 - PDZ domain (Also known as DHR or GLGF) PF09379 - FERM N-terminal domain PF09380 - FERM C-terminal PH-like domain PF16599 - Unstructured linker region on PTN13 protein between PDZ
SCOP Domains: 47031 - Second domain of FERM 101690 - PAZ domain 50156 - PDZ domain-like 50729 - PH domain-like 52799 - (Phosphotyrosine protein) phosphatases II 54236 - Ubiquitin-like
ModBase Predicted Comparative 3D Structure on Q12923
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.