ID:SPRL1_HUMAN DESCRIPTION: RecName: Full=SPARC-like protein 1; AltName: Full=High endothelial venule protein; Short=Hevin; AltName: Full=MAST 9; Flags: Precursor; SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). TISSUE SPECIFICITY: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes. PTM: N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. Thr-398 is the preferred site to Thr-399. SIMILARITY: Belongs to the SPARC family. SIMILARITY: Contains 1 EF-hand domain. SIMILARITY: Contains 1 follistatin-like domain. SIMILARITY: Contains 1 Kazal-like domain.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SPARCL1 CDC HuGE Published Literature: SPARCL1 Positive Disease Associations: Carotid Arteries Related Studies:
Carotid Arteries Christopher J O'Donnell et al. BMC medical genetics 2007, Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903303]
The results from this GWAS generate hypotheses regarding several SNPs that may be associated with SCA phenotypes in multiple arterial beds. Given the number of tests conducted, subsequent independent replication in a staged approach is essential to identify genetic variants that may be implicated in atherosclerosis.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14515
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0048856 anatomical structure development
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0005788 endoplasmic reticulum lumen
Descriptions from all associated GenBank mRNAs
BC022484 - Homo sapiens cDNA clone IMAGE:4799805, containing frame-shift errors. X82157 - H.sapiens mRNA for high endothelial venule. AL833430 - Homo sapiens mRNA; cDNA DKFZp313N0839 (from clone DKFZp313N0839). BC033721 - Homo sapiens SPARC-like 1 (hevin), mRNA (cDNA clone MGC:45264 IMAGE:4939390), complete cds. X86693 - H.sapiens mRNA for hevin like protein. BX647713 - Homo sapiens mRNA; cDNA DKFZp686F10266 (from clone DKFZp686F10266). JD049063 - Sequence 30087 from Patent EP1572962. AK304494 - Homo sapiens cDNA FLJ52396 complete cds, highly similar to SPARC-like protein 1 precursor. AK316533 - Homo sapiens cDNA, FLJ79432 complete cds, highly similar to SPARC-like protein 1 precursor. AK300956 - Homo sapiens cDNA FLJ54387 complete cds, moderately similar to SPARC-like protein 1 precursor. JD088923 - Sequence 69947 from Patent EP1572962. JD346126 - Sequence 327150 from Patent EP1572962. AK298039 - Homo sapiens cDNA FLJ54278 complete cds, highly similar to SPARC-like protein 1 precursor. JD273614 - Sequence 254638 from Patent EP1572962. AK304628 - Homo sapiens cDNA FLJ55140 complete cds, highly similar to SPARC-like protein 1 precursor. JD314455 - Sequence 295479 from Patent EP1572962. JD066869 - Sequence 47893 from Patent EP1572962. JD042179 - Sequence 23203 from Patent EP1572962. AY513278 - Homo sapiens proliferation-inducing protein 33 (PIG33) mRNA, complete cds. AK294335 - Homo sapiens cDNA FLJ50481 complete cds, highly similar to SPARC-like protein 1 precursor. EU832833 - Synthetic construct Homo sapiens clone HAIB:100067862; DKFZo008G0933 SPARC-like 1 (mast9, hevin) protein (SPARCL1) gene, encodes complete protein. GQ129224 - Synthetic construct Homo sapiens clone HAIB:100068524; DKFZo004G0934 SPARC-like 1 (mast9, hevin) protein (SPARCL1) gene, partial cds. BC010383 - Homo sapiens SPARC-like 1 (mast9, hevin), mRNA (cDNA clone IMAGE:4272629), with apparent retained intron. JD277569 - Sequence 258593 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q14515 (Reactome details) participates in the following event(s):
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification
US Server
