To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PPP3CA CDC HuGE Published Literature: PPP3CA Positive Disease Associations: Keratoconus Related Studies:
Keratoconus Xiaohui Li et al. Human molecular genetics 2012, A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries., Human molecular genetics.
[PubMed 21979947]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08209-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_gpcrPathway - Signaling Pathway from G-Protein Families h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_nos1Pathway - Nitric Oxide Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_tcrPathway - T Cell Receptor Signaling Pathway h_bcrPathway - BCR Signaling Pathway h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_pgc1aPathway - Regulation of PGC-1a h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors
Reactome (by CSHL, EBI, and GO)
Protein Q08209 (Reactome details) participates in the following event(s):
US Server
