ID:ADAD1_HUMAN DESCRIPTION: RecName: Full=Adenosine deaminase domain-containing protein 1; AltName: Full=Testis nuclear RNA-binding protein; FUNCTION: Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the ADAD family. SIMILARITY: Contains 1 A to I editase domain. SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
Celiac disease Hunt ,et al. 2008, Newly identified genetic risk variants for celiac disease related to the immune response, Nature genetics 2008 40- 4 : 395-402.
[PubMed 18311140]
Colitis, Ulcerative Carl A Anderson et al. Nature genetics 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47., Nature genetics.
[PubMed 21297633]
Diabetes Mellitus, Type 1 Paul R Burton et al. Nature 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls., Nature.
[PubMed 17554300]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96M93
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.