Description: Homo sapiens doublecortin-like kinase 2 (DCLK2), transcript variant 3, non-coding RNA. RefSeq Summary (NR_036614): This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]. Transcript (Including UTRs) Position: hg19 chr4:150,999,426-151,178,608 Size: 179,183 Total Exon Count: 17 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
LF206157 - JP 2014500723-A/13660: Polycomb-Associated Non-Coding RNAs. AB209181 - Homo sapiens mRNA for Hypothetical protein DKFZp761I032 variant protein. BC032726 - Homo sapiens cDNA clone IMAGE:5532881. AB384873 - Synthetic construct DNA, clone: pF1KB3903, Homo sapiens DCLK2 gene for serine/threonine-protein kinase DCLK2, complete cds, without stop codon, in Flexi system. DQ896665 - Synthetic construct Homo sapiens clone IMAGE:100011125; FLH196447.01L; RZPDo839D06155D doublecortin and CaM kinase-like 2 (DCAMKL2) gene, encodes complete protein. DQ890892 - Synthetic construct clone IMAGE:100003522; FLH166856.01X; RZPDo839E0388D doublecortin and CaM kinase-like 2 (DCAMKL2) gene, encodes complete protein. DQ893344 - Synthetic construct clone IMAGE:100005974; FLH196451.01X; RZPDo839D06156D doublecortin and CaM kinase-like 2 (DCAMKL2) gene, encodes complete protein. KJ905028 - Synthetic construct Homo sapiens clone ccsbBroadEn_14422 DCLK2-like gene, encodes complete protein. KJ905635 - Synthetic construct Homo sapiens clone ccsbBroadEn_15276 DCLK2 gene, encodes complete protein. BC172430 - Synthetic construct Homo sapiens clone IMAGE:100069124, MGC:199135 doublecortin-like kinase 2 (DCLK2) mRNA, encodes complete protein. AL834498 - Homo sapiens mRNA; cDNA DKFZp761I032 (from clone DKFZp761I032). MA441734 - JP 2018138019-A/13660: Polycomb-Associated Non-Coding RNAs. JD068357 - Sequence 49381 from Patent EP1572962. LF352044 - JP 2014500723-A/159547: Polycomb-Associated Non-Coding RNAs. MA587621 - JP 2018138019-A/159547: Polycomb-Associated Non-Coding RNAs. JD420782 - Sequence 401806 from Patent EP1572962. JD475084 - Sequence 456108 from Patent EP1572962. JD401879 - Sequence 382903 from Patent EP1572962. JD393726 - Sequence 374750 from Patent EP1572962. JD057857 - Sequence 38881 from Patent EP1572962. JD464974 - Sequence 445998 from Patent EP1572962. JD401172 - Sequence 382196 from Patent EP1572962. JD541699 - Sequence 522723 from Patent EP1572962. JD109837 - Sequence 90861 from Patent EP1572962. JD438775 - Sequence 419799 from Patent EP1572962. JD166999 - Sequence 148023 from Patent EP1572962. JD414145 - Sequence 395169 from Patent EP1572962. JD248707 - Sequence 229731 from Patent EP1572962. JD364877 - Sequence 345901 from Patent EP1572962. JD330725 - Sequence 311749 from Patent EP1572962. BC019831 - Homo sapiens doublecortin-like kinase 2, mRNA (cDNA clone IMAGE:4943185). JD552027 - Sequence 533051 from Patent EP1572962. JD391700 - Sequence 372724 from Patent EP1572962. JD217664 - Sequence 198688 from Patent EP1572962. JD153429 - Sequence 134453 from Patent EP1572962. JD307304 - Sequence 288328 from Patent EP1572962. JD567077 - Sequence 548101 from Patent EP1572962.