Human Gene DCLK2 (uc003ilp.4)
  Description: Homo sapiens doublecortin-like kinase 2 (DCLK2), transcript variant 3, non-coding RNA.
RefSeq Summary (NR_036614): This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].
Transcript (Including UTRs)
   Position: hg19 chr4:150,999,426-151,178,608 Size: 179,183 Total Exon Count: 17 Strand: +


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:150,999,426-151,178,608)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerH-INVHGNCLynx
PubMedTreefam

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.15 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 370.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF206157 - JP 2014500723-A/13660: Polycomb-Associated Non-Coding RNAs.
AB209181 - Homo sapiens mRNA for Hypothetical protein DKFZp761I032 variant protein.
BC032726 - Homo sapiens cDNA clone IMAGE:5532881.
AB384873 - Synthetic construct DNA, clone: pF1KB3903, Homo sapiens DCLK2 gene for serine/threonine-protein kinase DCLK2, complete cds, without stop codon, in Flexi system.
DQ896665 - Synthetic construct Homo sapiens clone IMAGE:100011125; FLH196447.01L; RZPDo839D06155D doublecortin and CaM kinase-like 2 (DCAMKL2) gene, encodes complete protein.
DQ890892 - Synthetic construct clone IMAGE:100003522; FLH166856.01X; RZPDo839E0388D doublecortin and CaM kinase-like 2 (DCAMKL2) gene, encodes complete protein.
DQ893344 - Synthetic construct clone IMAGE:100005974; FLH196451.01X; RZPDo839D06156D doublecortin and CaM kinase-like 2 (DCAMKL2) gene, encodes complete protein.
KJ905028 - Synthetic construct Homo sapiens clone ccsbBroadEn_14422 DCLK2-like gene, encodes complete protein.
KJ905635 - Synthetic construct Homo sapiens clone ccsbBroadEn_15276 DCLK2 gene, encodes complete protein.
BC172430 - Synthetic construct Homo sapiens clone IMAGE:100069124, MGC:199135 doublecortin-like kinase 2 (DCLK2) mRNA, encodes complete protein.
AL834498 - Homo sapiens mRNA; cDNA DKFZp761I032 (from clone DKFZp761I032).
MA441734 - JP 2018138019-A/13660: Polycomb-Associated Non-Coding RNAs.
JD068357 - Sequence 49381 from Patent EP1572962.
LF352044 - JP 2014500723-A/159547: Polycomb-Associated Non-Coding RNAs.
MA587621 - JP 2018138019-A/159547: Polycomb-Associated Non-Coding RNAs.
JD420782 - Sequence 401806 from Patent EP1572962.
JD475084 - Sequence 456108 from Patent EP1572962.
JD401879 - Sequence 382903 from Patent EP1572962.
JD393726 - Sequence 374750 from Patent EP1572962.
JD057857 - Sequence 38881 from Patent EP1572962.
JD464974 - Sequence 445998 from Patent EP1572962.
JD401172 - Sequence 382196 from Patent EP1572962.
JD541699 - Sequence 522723 from Patent EP1572962.
JD109837 - Sequence 90861 from Patent EP1572962.
JD438775 - Sequence 419799 from Patent EP1572962.
JD166999 - Sequence 148023 from Patent EP1572962.
JD414145 - Sequence 395169 from Patent EP1572962.
JD248707 - Sequence 229731 from Patent EP1572962.
JD364877 - Sequence 345901 from Patent EP1572962.
JD330725 - Sequence 311749 from Patent EP1572962.
BC019831 - Homo sapiens doublecortin-like kinase 2, mRNA (cDNA clone IMAGE:4943185).
JD552027 - Sequence 533051 from Patent EP1572962.
JD391700 - Sequence 372724 from Patent EP1572962.
JD217664 - Sequence 198688 from Patent EP1572962.
JD153429 - Sequence 134453 from Patent EP1572962.
JD307304 - Sequence 288328 from Patent EP1572962.
JD567077 - Sequence 548101 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_036614
UCSC ID: uc003ilp.4
RefSeq Accession: NR_036614

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: NR_036614.1
exon count: 17CDS single in 3' UTR: no RNA size: 4345
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3878.50frame shift in genome: no % Coverage: 99.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.