Description: Homo sapiens secreted frizzled-related protein 2 (SFRP2), mRNA. RefSeq Summary (NM_003013): This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr4:154,701,742-154,710,228 Size: 8,487 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr4:154,702,603-154,709,987 Size: 7,385 Coding Exon Count: 3
ID:SFRP2_HUMAN DESCRIPTION: RecName: Full=Secreted frizzled-related protein 2; Short=FRP-2; Short=sFRP-2; AltName: Full=Secreted apoptosis-related protein 1; Short=SARP-1; Flags: Precursor; FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. DOMAIN: The FZ domain is involved in binding with Wnt ligands (By similarity). SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP) family. SIMILARITY: Contains 1 FZ (frizzled) domain. SIMILARITY: Contains 1 NTR domain.
Albuminuria Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903292]
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
Apolipoproteins C Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96HF1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF206154 - JP 2014500723-A/13657: Polycomb-Associated Non-Coding RNAs. AF311912 - Homo sapiens pancreas tumor-related protein (FKSG12) mRNA, complete cds. AK075372 - Homo sapiens cDNA PSEC0060 fis, clone NT2RP2000638, highly similar to Secreted frizzled-related protein 2 precursor. AK093922 - Homo sapiens cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2 precursor. JD163071 - Sequence 144095 from Patent EP1572962. JD310932 - Sequence 291956 from Patent EP1572962. JD184531 - Sequence 165555 from Patent EP1572962. LF351996 - JP 2014500723-A/159499: Polycomb-Associated Non-Coding RNAs. BC008666 - Homo sapiens secreted frizzled-related protein 2, mRNA (cDNA clone MGC:9395 IMAGE:3874262), complete cds. AY359001 - Homo sapiens clone DNA50920 sFRP-2 (UNQ361) mRNA, complete cds. LF351995 - JP 2014500723-A/159498: Polycomb-Associated Non-Coding RNAs. JD514261 - Sequence 495285 from Patent EP1572962. JD200645 - Sequence 181669 from Patent EP1572962. JD508756 - Sequence 489780 from Patent EP1572962. JD145996 - Sequence 127020 from Patent EP1572962. JD521064 - Sequence 502088 from Patent EP1572962. JD150196 - Sequence 131220 from Patent EP1572962. JD325122 - Sequence 306146 from Patent EP1572962. JD252904 - Sequence 233928 from Patent EP1572962. HM005483 - Homo sapiens clone HTL-T-170 testicular tissue protein Li 170 mRNA, complete cds. JD064805 - Sequence 45829 from Patent EP1572962. JD134477 - Sequence 115501 from Patent EP1572962. JD375816 - Sequence 356840 from Patent EP1572962. KJ897541 - Synthetic construct Homo sapiens clone ccsbBroadEn_06935 SFRP2 gene, encodes complete protein. AB464189 - Synthetic construct DNA, clone: pF1KB6354, Homo sapiens SFRP2 gene for secreted frizzled-related protein 2, without stop codon, in Flexi system. LF351994 - JP 2014500723-A/159497: Polycomb-Associated Non-Coding RNAs. AF017986 - Homo sapiens secreted apoptosis related protein 1 (SFRP2) mRNA, partial cds. LF211898 - JP 2014500723-A/19401: Polycomb-Associated Non-Coding RNAs. JD520561 - Sequence 501585 from Patent EP1572962. MA587573 - JP 2018138019-A/159499: Polycomb-Associated Non-Coding RNAs. MA587572 - JP 2018138019-A/159498: Polycomb-Associated Non-Coding RNAs. MA587571 - JP 2018138019-A/159497: Polycomb-Associated Non-Coding RNAs. MA441731 - JP 2018138019-A/13657: Polycomb-Associated Non-Coding RNAs. MA447475 - JP 2018138019-A/19401: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04310 - Wnt signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein Q96HF1 (Reactome details) participates in the following event(s):
R-HSA-3772441 sFRP binds WNT3A and inhibits WNT:FZD binding R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-195721 Signaling by WNT R-HSA-162582 Signal Transduction