Description: Homo sapiens guanylate cyclase 1, soluble, alpha 3 (GUCY1A1), transcript variant 2, mRNA. RefSeq Summary (NM_001130682): Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr4:156,587,862-156,658,214 Size: 70,353 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr4:156,618,020-156,651,383 Size: 33,364 Coding Exon Count: 8
ID:GCYA3_HUMAN DESCRIPTION: RecName: Full=Guanylate cyclase soluble subunit alpha-3; Short=GCS-alpha-3; EC=4.6.1.2; AltName: Full=GCS-alpha-1; AltName: Full=Soluble guanylate cyclase large subunit; CATALYTIC ACTIVITY: GTP = 3',5'-cyclic GMP + diphosphate. ENZYME REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. SUBUNIT: Heterodimer of an alpha and a beta chain. SUBCELLULAR LOCATION: Cytoplasm. MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. SIMILARITY: Contains 1 guanylate cyclase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02108
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006182 cGMP biosynthetic process GO:0007263 nitric oxide mediated signal transduction GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009190 cyclic nucleotide biosynthetic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0035556 intracellular signal transduction GO:0052565 response to defense-related host nitric oxide production GO:0060087 relaxation of vascular smooth muscle
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