ID:CBR4_HUMAN DESCRIPTION: RecName: Full=Carbonyl reductase family member 4; EC=1.-.-.-; AltName: Full=3-oxoacyl-[acyl-carrier-protein] reductase; EC=1.1.1.-; AltName: Full=Quinone reductase CBR4; FUNCTION: The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=11 uM for NADPH; KM=1.6 uM for 9,10-phenanthrenequinone; KM=1.9 uM for 1,4-benzoquinone; pH dependence: Optimum pH is 6-8; PATHWAY: Lipid metabolism; fatty acid biosynthesis. SUBUNIT: Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4. SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Detected in liver and kidney (at protein level). SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CBR4 CDC HuGE Published Literature: CBR4 Positive Disease Associations: Body Height
, Myocardial Infarction Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N4T8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0044597 daunorubicin metabolic process GO:0044598 doxorubicin metabolic process GO:0051289 protein homotetramerization GO:0051290 protein heterotetramerization GO:0055114 oxidation-reduction process