Human Gene APC (uc003kpz.4)
  Description: Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA.
RefSeq Summary (NM_001127510): This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019].
Transcript (Including UTRs)
   Position: hg19 chr5:112,073,556-112,181,936 Size: 108,381 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr5:112,090,588-112,179,823 Size: 89,236 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviews
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:112,073,556-112,181,936)mRNA (may differ from genome)Protein (2843 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMalacardsMGIneXtProtOMIM
PubMedReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: APC_HUMAN
DESCRIPTION: RecName: Full=Adenomatous polyposis coli protein; Short=Protein APC; AltName: Full=Deleted in polyposis 2.5;
FUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
SUBUNIT: Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity). Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts at the cell membrane with FAM123A and FAM123B (via ARM repeats).
INTERACTION: P35222:CTNNB1; NbExp=7; IntAct=EBI-727707, EBI-491549; Q02248:Ctnnb1 (xeno); NbExp=8; IntAct=EBI-727707, EBI-397872; Q15691:MAPRE1; NbExp=4; IntAct=EBI-727707, EBI-1004115;
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
TISSUE SPECIFICITY: Expressed in a variety of tissues.
DOMAIN: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends (By similarity).
PTM: Phosphorylated by GSK3B.
PTM: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.
DISEASE: Defects in APC are a cause of familial adenomatous polyposis (FAP) [MIM:175100]; which includes also Gardner syndrome (GS). FAP and GS contribute to tumor development in patients with uninherited forms of colorectal cancer. FAP is characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years.
DISEASE: Defects in APC are a cause of hereditary desmoid disease (HDD) [MIM:135290]; also known as familial infiltrative fibromatosis (FIF). HDD is an autosomal dominant trait with 100% penetrance and possible variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a complication of familial adenomatous polyposis.
DISEASE: Defects in APC are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome).
DISEASE: Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) [MIM:276300]; also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.
DISEASE: Defects in APC are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
DISEASE: Defects in APC are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. This defect includes also the disease entity termed hepatoblastoma.
MISCELLANEOUS: APC mutations have led to some interesting observations. (1) the great majority of the mutations found to date would result in truncation of the APC product. (2) almost all the mutations have occurred within the first half of the coding sequence, and somatic mutations in colorectal tumors are further clustered in a particular region, called MCR (mutation cluster region). (3) most identified point mutations in the APC gene are transitions from cytosine to other nucleotides. (4) the location of germline mutations tends to correlate with the number of colorectal polyps in FAP patients. Inactivation of both alleles of the APC gene seems to be required as an early event to develop most adenomas and carcinomas in the colon and rectum as well as some of those in the stomach.
SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
SIMILARITY: Contains 7 ARM repeats.
WEB RESOURCE: Name=Colon cancer gene variant databases Adenomatous Polyposis Coli (APC); Note=Leiden Open Variation Database (LOVD); URL="http://chromium.liacs.nl/LOVD2/colon_cancer/home.php?select_db=APC";
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/APC118.html";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/APC";
WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APC";
WEB RESOURCE: Name=Wikipedia; Note=APC entry; URL="http://en.wikipedia.org/wiki/APC_%28gene%29";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): APC
CDC HuGE Published Literature: APC
Positive Disease Associations: adenomatous polyposis , adenomatous polyposis coli , autism , beta-catenin , Cholesterol , colon adenomas/carcinomas , colorectal adenocarcinomas , colorectal adenomas , colorectal cancer , decreased apoptotic level , diet lifestyle and risk of colon cancer , familial adenomatous polyposis. , hepatocellular carcinoma , late onset familial adenomatous polyposis , late onset of familial adenomatous polyposis , severe desmoid phenotype , stomach cancer , Stroke , venous thrombosis
Related Studies:
  1. adenomatous polyposis
    de Silva DC et al. 1996, Cranial desmoid tumor associated with homozygous inactivation of the adenomatous polyposis coli gene in a 2-year-old girl with familial adenomatous polyposis., Cancer. 1996 Mar;77(5):972-6. [PubMed 8608492]
    These findings are compatible with the presence of a second hit inactivation of the APC gene and implicate this gene in the pathogenesis of desmoid tumors.
  2. adenomatous polyposis coli
    Gayther SA et al. 1994, Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli., Human molecular genetics. 1994 Jan;3(1):53-6. [PubMed 8162051]
  3. autism
    Zhou, X. L. et al. 2007, Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD), Am J Med Genet B Neuropsychiatr Genet 2007. [PubMed 17221838]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: APC
Diseases sorted by gene-association score: adenomatous polyposis coli* (1761), desmoid disease, hereditary* (1350), gastric cancer, somatic* (1207), familial adenomatous polyposis* (597), colorectal cancer* (500), desmoid tumor* (430), hepatoblastoma* (426), periampullary adenoma* (400), gastric adenocarcinoma and proximal polyposis of the stomach* (368), hepatocellular carcinoma* (349), cenani-lenz syndactyly syndrome* (247), stomach cancer* (207), medulloblastoma* (141), attenuated familial adenomatous polyposis* (119), apc-associated polyposis conditions* (100), familial adenomatous polyposis due to 5q22.2 microdeletion* (25), fourth cranial nerve palsy (18), cranial nerve palsy (18), familial colorectal cancer (18), fibromatosis (15), hereditary mixed polyposis syndrome 1 (12), mutyh-associated polyposis (11), peutz-jeghers syndrome (9), pseudohypoparathyroidism (9), anal squamous cell carcinoma (9), mccune-albright syndrome, somatic, mosaic (9), mismatch repair cancer syndrome (9), hereditary colorectal cancer (9), hyperplastic polyposis syndrome (9), lynch syndrome (8), brachydactyly, type e (8), polyposis, juvenile intestinal (7), fibrous dysplasia (7), breast cancer (7), intestinal benign neoplasm (7), brca2 hereditary breast and ovarian cancer syndrome (6), brca1 hereditary breast and ovarian cancer syndrome (6), acinar cell carcinoma (6), colon adenoma (5), colonic benign neoplasm (5), hepatic adenoma, somatic (5), adenoma (4), pilocytic astrocytoma (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C029216 2-amino-3-methylimidazo(4,5-f)quinoline
  • C027576 4-hydroxy-2-nonenal
  • D007213 Indomethacin
  • D014212 Tretinoin
  • C072581 16-hydroxycleroda-3,13(14)-dien-15,16-olide
  • C023514 2,6-dinitrotoluene
  • C502239 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct
  • C026137 3-hydroxyacetanilide
  • C406867 4-hydroxynonenoic acid
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.42 RPKM in Brain - Amygdala
Total median expression: 300.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.00193-0.321 Picture PostScript Text
3' UTR -500.612113-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026836 - APC
IPR009240 - APC_15aa_rpt
IPR009234 - APC_basic_dom
IPR009223 - APC_Cys-rich_rpt
IPR026831 - APC_dom
IPR026818 - Apc_fam
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo
IPR009232 - EB1-bd
IPR009224 - SAMP

Pfam Domains:
PF00514 - Armadillo/beta-catenin-like repeat
PF05923 - APC repeat
PF05924 - SAMP Motif
PF05937 - EB-1 Binding Domain
PF05956 - APC basic domain
PF05972 - APC 15 residue motif
PF11414 - Adenomatous polyposis coli tumour suppressor protein
PF16629 - Armadillo-associated region on APC
PF16630 - Unstructured region on APC between 1st and 2nd catenin-bdg motifs
PF16633 - Unstructured region on APC between 1st two creatine-rich regions
PF16634 - Unstructured region on APC between APC_crr and SAMP
PF16635 - Unstructured region on APC between SAMP and APC_crr
PF16636 - Unstructured region on APC between APC_crr regions 5 and 6
PF16689 - Coiled-coil N-terminus of APC, dimerisation domain

SCOP Domains:
48371 - ARM repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1DEB - X-ray MuPIT 1EMU - X-ray MuPIT 1JPP - X-ray 1M5I - X-ray MuPIT 1T08 - X-ray MuPIT 1TH1 - X-ray MuPIT 1V18 - X-ray MuPIT 2RQU - NMR MuPIT 3AU3 - X-ray MuPIT 3NMW - X-ray MuPIT 3NMX - X-ray MuPIT 3NMZ - X-ray MuPIT 3QHE - X-ray MuPIT 3RL7 - X-ray MuPIT 3RL8 - X-ray MuPIT 3T7U - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P25054
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0045295 gamma-catenin binding
GO:0051010 microtubule plus-end binding
GO:0070840 dynein complex binding
GO:0045296 cadherin binding

Biological Process:
GO:0000281 mitotic cytokinesis
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007050 cell cycle arrest
GO:0007094 mitotic spindle assembly checkpoint
GO:0007155 cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010942 positive regulation of cell death
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030335 positive regulation of cell migration
GO:0031274 positive regulation of pseudopodium assembly
GO:0032886 regulation of microtubule-based process
GO:0043065 positive regulation of apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051260 protein homooligomerization
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0060070 canonical Wnt signaling pathway
GO:0065003 macromolecular complex assembly
GO:0070830 bicellular tight junction assembly
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904781 positive regulation of protein localization to centrosome
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly

Cellular Component:
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 bicellular tight junction
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030877 beta-catenin destruction complex
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm
GO:1990909 Wnt signalosome
GO:0005913 cell-cell adherens junction


-  Descriptions from all associated GenBank mRNAs
  LF211001 - JP 2014500723-A/18504: Polycomb-Associated Non-Coding RNAs.
LC085427 - Homo sapiens APC mRNA for adenomatous polyposis coli protein isoform b, complete cds.
LC085428 - Homo sapiens APC mRNA for adenomatous polyposis coli protein isoform t, complete cds.
AK294544 - Homo sapiens cDNA FLJ50140 partial cds, highly similar to Adenomatous polyposis coli protein.
LF214049 - JP 2014500723-A/21552: Polycomb-Associated Non-Coding RNAs.
MA449626 - JP 2018138019-A/21552: Polycomb-Associated Non-Coding RNAs.
MA446578 - JP 2018138019-A/18504: Polycomb-Associated Non-Coding RNAs.
BC034955 - Homo sapiens cDNA clone IMAGE:4824797, containing frame-shift errors.
BC056268 - Homo sapiens adenomatous polyposis coli, mRNA (cDNA clone IMAGE:6744334), partial cds.
AB210001 - Homo sapiens mRNA for APC variant protein, clone: ff03440.
AK289567 - Homo sapiens cDNA FLJ75530 partial cds, highly similar to Human APC gene mRNA.
LF342991 - JP 2014500723-A/150494: Polycomb-Associated Non-Coding RNAs.
S56365 - APC=adenomatous polyposis coli {5' untranslated region, alternatively spliced} [human, fetal brain, mRNA, 123 nt].
M73548 - Human polyposis locus (DP2.5 gene) mRNA, complete cds.
M74088 - Human APC gene mRNA, complete cds.
AB384669 - Synthetic construct DNA, clone: pF1KB0019, Homo sapiens APC gene for adenomatous polyposis coli protein, complete cds, without stop codon, in Flexi system.
BC111462 - Synthetic construct Homo sapiens clone IMAGE:40080641, MGC:133429 APC protein (APC) mRNA, encodes complete protein.
BC111930 - Synthetic construct Homo sapiens clone IMAGE:40080737, MGC:133450 APC protein (APC) mRNA, encodes complete protein.
BC113358 - Synthetic construct Homo sapiens clone IMAGE:40080833, MGC:133387 adenomatosis polyposis coli (APC) mRNA, encodes complete protein.
BC111591 - Synthetic construct Homo sapiens clone IMAGE:40080545, MGC:133408 APC protein (APC) mRNA, encodes complete protein.
GQ900989 - Homo sapiens clone HEL-T-101 epididymis secretory sperm binding protein mRNA, complete cds.
LF342994 - JP 2014500723-A/150497: Polycomb-Associated Non-Coding RNAs.
LF342997 - JP 2014500723-A/150500: Polycomb-Associated Non-Coding RNAs.
LF342998 - JP 2014500723-A/150501: Polycomb-Associated Non-Coding RNAs.
LF342999 - JP 2014500723-A/150502: Polycomb-Associated Non-Coding RNAs.
S67787 - APC [human, adenomatous polyposis coli kindreds 347 and 139, mRNA Partial Mutant, 115 nt].
S67788 - APC [human, adenomatous polyposis coli kindreds 347 and 139, mRNA Partial Mutant, 117 nt].
S67789 - APC [human, adenomatous polyposis coli kindreds 347 and 139, mRNA Partial Mutant, 117 nt].
LF343003 - JP 2014500723-A/150506: Polycomb-Associated Non-Coding RNAs.
LF343004 - JP 2014500723-A/150507: Polycomb-Associated Non-Coding RNAs.
AK309033 - Homo sapiens cDNA, FLJ99074.
AF038181 - Homo sapiens clone 23607 mRNA sequence.
LF343005 - JP 2014500723-A/150508: Polycomb-Associated Non-Coding RNAs.
LF343006 - JP 2014500723-A/150509: Polycomb-Associated Non-Coding RNAs.
LF343007 - JP 2014500723-A/150510: Polycomb-Associated Non-Coding RNAs.
LF343008 - JP 2014500723-A/150511: Polycomb-Associated Non-Coding RNAs.
LF343009 - JP 2014500723-A/150512: Polycomb-Associated Non-Coding RNAs.
LF343010 - JP 2014500723-A/150513: Polycomb-Associated Non-Coding RNAs.
LF343011 - JP 2014500723-A/150514: Polycomb-Associated Non-Coding RNAs.
DQ317525 - Homo sapiens truncated adenomatosis polyposis coli (APC) mRNA, partial cds.
LF343012 - JP 2014500723-A/150515: Polycomb-Associated Non-Coding RNAs.
LF343013 - JP 2014500723-A/150516: Polycomb-Associated Non-Coding RNAs.
LF343014 - JP 2014500723-A/150517: Polycomb-Associated Non-Coding RNAs.
DQ320123 - Homo sapiens mutant adenomatosis polyposis coli (APC) mRNA, partial sequence.
LF343015 - JP 2014500723-A/150518: Polycomb-Associated Non-Coding RNAs.
LF343016 - JP 2014500723-A/150519: Polycomb-Associated Non-Coding RNAs.
LF343017 - JP 2014500723-A/150520: Polycomb-Associated Non-Coding RNAs.
LF343018 - JP 2014500723-A/150521: Polycomb-Associated Non-Coding RNAs.
LF343019 - JP 2014500723-A/150522: Polycomb-Associated Non-Coding RNAs.
LF343020 - JP 2014500723-A/150523: Polycomb-Associated Non-Coding RNAs.
LF343021 - JP 2014500723-A/150524: Polycomb-Associated Non-Coding RNAs.
LF343022 - JP 2014500723-A/150525: Polycomb-Associated Non-Coding RNAs.
LF343023 - JP 2014500723-A/150526: Polycomb-Associated Non-Coding RNAs.
LF343024 - JP 2014500723-A/150527: Polycomb-Associated Non-Coding RNAs.
LF343025 - JP 2014500723-A/150528: Polycomb-Associated Non-Coding RNAs.
JD315043 - Sequence 296067 from Patent EP1572962.
JD359588 - Sequence 340612 from Patent EP1572962.
LF343026 - JP 2014500723-A/150529: Polycomb-Associated Non-Coding RNAs.
JD201978 - Sequence 183002 from Patent EP1572962.
JD166371 - Sequence 147395 from Patent EP1572962.
JD377360 - Sequence 358384 from Patent EP1572962.
JD503214 - Sequence 484238 from Patent EP1572962.
JD042620 - Sequence 23644 from Patent EP1572962.
JD429709 - Sequence 410733 from Patent EP1572962.
JD110063 - Sequence 91087 from Patent EP1572962.
JD080334 - Sequence 61358 from Patent EP1572962.
JD213991 - Sequence 195015 from Patent EP1572962.
JD375554 - Sequence 356578 from Patent EP1572962.
MH183200 - Homo sapiens adenomatous polyposis coli (APC) mRNA, partial sequence.
MH183199 - Homo sapiens adenomatous polyposis coli (APC) mRNA, partial sequence.
MA578568 - JP 2018138019-A/150494: Polycomb-Associated Non-Coding RNAs.
MA578571 - JP 2018138019-A/150497: Polycomb-Associated Non-Coding RNAs.
MA578574 - JP 2018138019-A/150500: Polycomb-Associated Non-Coding RNAs.
MA578575 - JP 2018138019-A/150501: Polycomb-Associated Non-Coding RNAs.
MA578576 - JP 2018138019-A/150502: Polycomb-Associated Non-Coding RNAs.
MA578580 - JP 2018138019-A/150506: Polycomb-Associated Non-Coding RNAs.
MA578581 - JP 2018138019-A/150507: Polycomb-Associated Non-Coding RNAs.
MA578582 - JP 2018138019-A/150508: Polycomb-Associated Non-Coding RNAs.
MA578583 - JP 2018138019-A/150509: Polycomb-Associated Non-Coding RNAs.
MA578584 - JP 2018138019-A/150510: Polycomb-Associated Non-Coding RNAs.
MA578585 - JP 2018138019-A/150511: Polycomb-Associated Non-Coding RNAs.
MA578586 - JP 2018138019-A/150512: Polycomb-Associated Non-Coding RNAs.
MA578587 - JP 2018138019-A/150513: Polycomb-Associated Non-Coding RNAs.
MA578588 - JP 2018138019-A/150514: Polycomb-Associated Non-Coding RNAs.
MA578589 - JP 2018138019-A/150515: Polycomb-Associated Non-Coding RNAs.
MA578590 - JP 2018138019-A/150516: Polycomb-Associated Non-Coding RNAs.
MA578591 - JP 2018138019-A/150517: Polycomb-Associated Non-Coding RNAs.
MA578592 - JP 2018138019-A/150518: Polycomb-Associated Non-Coding RNAs.
MA578593 - JP 2018138019-A/150519: Polycomb-Associated Non-Coding RNAs.
MA578594 - JP 2018138019-A/150520: Polycomb-Associated Non-Coding RNAs.
MA578595 - JP 2018138019-A/150521: Polycomb-Associated Non-Coding RNAs.
MA578596 - JP 2018138019-A/150522: Polycomb-Associated Non-Coding RNAs.
MA578597 - JP 2018138019-A/150523: Polycomb-Associated Non-Coding RNAs.
MA578598 - JP 2018138019-A/150524: Polycomb-Associated Non-Coding RNAs.
MA578599 - JP 2018138019-A/150525: Polycomb-Associated Non-Coding RNAs.
MA578600 - JP 2018138019-A/150526: Polycomb-Associated Non-Coding RNAs.
MA578601 - JP 2018138019-A/150527: Polycomb-Associated Non-Coding RNAs.
MA578602 - JP 2018138019-A/150528: Polycomb-Associated Non-Coding RNAs.
MA578603 - JP 2018138019-A/150529: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04310 - Wnt signaling pathway
hsa04810 - Regulation of actin cytoskeleton
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05213 - Endometrial cancer
hsa05217 - Basal cell carcinoma

BioCarta from NCI Cancer Genome Anatomy Project
h_tgfbPathway - TGF beta signaling pathway
h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
h_ps1Pathway - Presenilin action in Notch and Wnt signaling
h_alkPathway - ALK in cardiac myocytes
h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2
h_wntPathway - WNT Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P25054 (Reactome details) participates in the following event(s):

R-NUL-209144 Human APC is finally phosphorylated by Murine GSK3beta
R-NUL-209065 Human APC is further phosphorylated by Murine CKIepsilon
R-NUL-209060 Human APC is further phosphorylated by Murine GSK3beta
R-NUL-209132 Human APC is initially phosphorylated by Murine CKIepsilon
R-HSA-202947 Caspase mediated cleavage of APC
R-HSA-5246693 APC is K63-polyubiquitinated
R-HSA-195251 Assembly of the destruction complex
R-HSA-6781905 ZRANB1 binds APC
R-HSA-201685 Beta-catenin is released from the destruction complex
R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
R-HSA-195275 Phosphorylation of APC component of the destruction complex
R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
R-HSA-5229343 AXIN is phosphorylated in the destruction complex
R-HSA-195304 Association of beta-catenin with the destruction complex
R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha
R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-75153 Apoptotic execution phase
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated
R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-4839748 AMER1 mutants destabilize the destruction complex
R-HSA-5688426 Deubiquitination
R-HSA-109581 Apoptosis
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-162582 Signal Transduction
R-HSA-4839744 truncated APC mutants destabilize the destruction complex
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-597592 Post-translational protein modification
R-HSA-5357801 Programmed Cell Death
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-5663202 Diseases of signal transduction
R-HSA-392499 Metabolism of proteins
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: APC_HUMAN, D3DT03, DP2.5, NM_001127510, NP_001120982, P25054, Q15162, Q15163, Q93042
UCSC ID: uc003kpz.4
RefSeq Accession: NM_001127510
Protein: P25054 (aka APC_HUMAN)
CCDS: CCDS4107.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene APC:
fap (APC-Associated Polyposis Conditions)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001127510.2
exon count: 17CDS single in 3' UTR: no RNA size: 10848
ORF size: 8532CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 16727.00frame shift in genome: no % Coverage: 99.91
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.