Description: Homo sapiens sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (SPOCK1), mRNA. RefSeq Summary (NM_004598): This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr5:136,310,987-136,834,438 Size: 523,452 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr5:136,314,343-136,834,247 Size: 519,905 Coding Exon Count: 10
ID:TICN1_HUMAN DESCRIPTION: RecName: Full=Testican-1; AltName: Full=Protein SPOCK; Flags: Precursor; FUNCTION: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. PTM: Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides. SIMILARITY: Contains 1 Kazal-like domain. SIMILARITY: Contains 1 thyroglobulin type-1 domain. SEQUENCE CAUTION: Sequence=BAD92938.1; Type=Erroneous initiation;
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SPOCK1 CDC HuGE Published Literature: SPOCK1 Positive Disease Associations: Creatinine
, Diabetes Mellitus Related Studies:
Creatinine Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903292]
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08629
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001558 regulation of cell growth GO:0001764 neuron migration GO:0007155 cell adhesion GO:0007165 signal transduction GO:0007399 nervous system development GO:0010812 negative regulation of cell-substrate adhesion GO:0010951 negative regulation of endopeptidase activity GO:0010977 negative regulation of neuron projection development GO:0021953 central nervous system neuron differentiation GO:0022008 neurogenesis