Human Gene DPYSL3 (uc003loo.3)
  Description: Homo sapiens dihydropyrimidinase-like 3 (DPYSL3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:146,770,371-146,889,619 Size: 119,249 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr5:146,773,598-146,889,421 Size: 115,824 Coding Exon Count: 14 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:146,770,371-146,889,619)mRNA (may differ from genome)Protein (684 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMalacardsMGIOMIM
PubMedReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DPYSL3
CDC HuGE Published Literature: DPYSL3
Positive Disease Associations: Audiometry, Pure-Tone , Lipoproteins
Related Studies:
  1. Audiometry, Pure-Tone
    , , . [PubMed 0]
  2. Lipoproteins
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: DPYSL3
Diseases sorted by gene-association score: hypertensive encephalopathy (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 137.96 RPKM in Esophagus - Muscularis
Total median expression: 1655.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.10198-0.465 Picture PostScript Text
3' UTR -1041.543227-0.323 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01979 - Amidohydrolase family

SCOP Domains:
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases

ModBase Predicted Comparative 3D Structure on Q14195-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  LF211039 - JP 2014500723-A/18542: Polycomb-Associated Non-Coding RNAs.
D78014 - Homo sapiens mRNA for dihydropyrimidinase related protein-3, complete cds.
BC077077 - Homo sapiens dihydropyrimidinase-like 3, mRNA (cDNA clone MGC:88094 IMAGE:6177053), complete cds.
BC039006 - Homo sapiens dihydropyrimidinase-like 3, mRNA (cDNA clone MGC:47771 IMAGE:5725550), complete cds.
AK297223 - Homo sapiens cDNA FLJ57528 complete cds, highly similar to Dihydropyrimidinase-related protein 3.
Y07818 - H.sapiens mRNA for ULIP phosphoprotein.
EU007906 - Homo sapiens collapsin response mediator protein 4 long variant (LCRMP) mRNA, complete cds, alternatively spliced.
HM005547 - Homo sapiens clone HTL-S-7 testicular secretory protein Li 7 mRNA, complete cds.
KJ896724 - Synthetic construct Homo sapiens clone ccsbBroadEn_06118 DPYSL3 gene, encodes complete protein.
AB384367 - Synthetic construct DNA, clone: pF1KSDB0029, Homo sapiens DPYSL3 gene for dihydropyrimidinase-related protein 3, complete cds, without stop codon, in Flexi system.
KJ896725 - Synthetic construct Homo sapiens clone ccsbBroadEn_06119 DPYSL3 gene, encodes complete protein.
EU832180 - Synthetic construct Homo sapiens clone HAIB:100067209; DKFZo008H1125 dihydropyrimidinase-like 3 protein (DPYSL3) gene, encodes complete protein.
EU832273 - Synthetic construct Homo sapiens clone HAIB:100067302; DKFZo004H1126 dihydropyrimidinase-like 3 protein (DPYSL3) gene, encodes complete protein.
EU832163 - Synthetic construct Homo sapiens clone HAIB:100067192; DKFZo008G0625 dihydropyrimidinase-like 3 protein (DPYSL3) gene, encodes complete protein.
EU832257 - Synthetic construct Homo sapiens clone HAIB:100067286; DKFZo004G0626 dihydropyrimidinase-like 3 protein (DPYSL3) gene, encodes complete protein.
CU691634 - Synthetic construct Homo sapiens gateway clone IMAGE:100020881 5' read DPYSL3 mRNA.
CU687310 - Synthetic construct Homo sapiens gateway clone IMAGE:100023011 5' read DPYSL3 mRNA.
MA446616 - JP 2018138019-A/18542: Polycomb-Associated Non-Coding RNAs.
CQ903795 - Sequence 1 from Patent WO2004094660.
JD494895 - Sequence 475919 from Patent EP1572962.
JD496036 - Sequence 477060 from Patent EP1572962.
JD355052 - Sequence 336076 from Patent EP1572962.
JD120821 - Sequence 101845 from Patent EP1572962.
LF343366 - JP 2014500723-A/150869: Polycomb-Associated Non-Coding RNAs.
LF343367 - JP 2014500723-A/150870: Polycomb-Associated Non-Coding RNAs.
JD504231 - Sequence 485255 from Patent EP1572962.
JD514743 - Sequence 495767 from Patent EP1572962.
JD147464 - Sequence 128488 from Patent EP1572962.
JD394290 - Sequence 375314 from Patent EP1572962.
JD457841 - Sequence 438865 from Patent EP1572962.
JD102499 - Sequence 83523 from Patent EP1572962.
JD153457 - Sequence 134481 from Patent EP1572962.
JD335934 - Sequence 316958 from Patent EP1572962.
JD467513 - Sequence 448537 from Patent EP1572962.
JD185532 - Sequence 166556 from Patent EP1572962.
JD063682 - Sequence 44706 from Patent EP1572962.
JD334312 - Sequence 315336 from Patent EP1572962.
LF343368 - JP 2014500723-A/150871: Polycomb-Associated Non-Coding RNAs.
JD489833 - Sequence 470857 from Patent EP1572962.
LF343369 - JP 2014500723-A/150872: Polycomb-Associated Non-Coding RNAs.
JD434177 - Sequence 415201 from Patent EP1572962.
JD299294 - Sequence 280318 from Patent EP1572962.
JD130614 - Sequence 111638 from Patent EP1572962.
JD168801 - Sequence 149825 from Patent EP1572962.
JD205206 - Sequence 186230 from Patent EP1572962.
JD092983 - Sequence 74007 from Patent EP1572962.
JD507980 - Sequence 489004 from Patent EP1572962.
JD248371 - Sequence 229395 from Patent EP1572962.
JD278967 - Sequence 259991 from Patent EP1572962.
LF343370 - JP 2014500723-A/150873: Polycomb-Associated Non-Coding RNAs.
JD527126 - Sequence 508150 from Patent EP1572962.
JD152774 - Sequence 133798 from Patent EP1572962.
JD176773 - Sequence 157797 from Patent EP1572962.
JD041710 - Sequence 22734 from Patent EP1572962.
JD352607 - Sequence 333631 from Patent EP1572962.
JD298878 - Sequence 279902 from Patent EP1572962.
JD158658 - Sequence 139682 from Patent EP1572962.
JD436475 - Sequence 417499 from Patent EP1572962.
JD492178 - Sequence 473202 from Patent EP1572962.
JD289444 - Sequence 270468 from Patent EP1572962.
JD164083 - Sequence 145107 from Patent EP1572962.
JD316396 - Sequence 297420 from Patent EP1572962.
JD233796 - Sequence 214820 from Patent EP1572962.
JD556576 - Sequence 537600 from Patent EP1572962.
LF343371 - JP 2014500723-A/150874: Polycomb-Associated Non-Coding RNAs.
JD481899 - Sequence 462923 from Patent EP1572962.
JD343328 - Sequence 324352 from Patent EP1572962.
JD340317 - Sequence 321341 from Patent EP1572962.
JD225545 - Sequence 206569 from Patent EP1572962.
JD176692 - Sequence 157716 from Patent EP1572962.
JD443717 - Sequence 424741 from Patent EP1572962.
JD231953 - Sequence 212977 from Patent EP1572962.
JD359039 - Sequence 340063 from Patent EP1572962.
JD196604 - Sequence 177628 from Patent EP1572962.
JD047210 - Sequence 28234 from Patent EP1572962.
JD563146 - Sequence 544170 from Patent EP1572962.
JD091034 - Sequence 72058 from Patent EP1572962.
JD310334 - Sequence 291358 from Patent EP1572962.
JD474251 - Sequence 455275 from Patent EP1572962.
JD077229 - Sequence 58253 from Patent EP1572962.
LF343372 - JP 2014500723-A/150875: Polycomb-Associated Non-Coding RNAs.
LF343374 - JP 2014500723-A/150877: Polycomb-Associated Non-Coding RNAs.
LF343375 - JP 2014500723-A/150878: Polycomb-Associated Non-Coding RNAs.
LF343377 - JP 2014500723-A/150880: Polycomb-Associated Non-Coding RNAs.
LF343378 - JP 2014500723-A/150881: Polycomb-Associated Non-Coding RNAs.
LF343379 - JP 2014500723-A/150882: Polycomb-Associated Non-Coding RNAs.
LF343380 - JP 2014500723-A/150883: Polycomb-Associated Non-Coding RNAs.
LF343381 - JP 2014500723-A/150884: Polycomb-Associated Non-Coding RNAs.
LF343382 - JP 2014500723-A/150885: Polycomb-Associated Non-Coding RNAs.
MA578943 - JP 2018138019-A/150869: Polycomb-Associated Non-Coding RNAs.
MA578944 - JP 2018138019-A/150870: Polycomb-Associated Non-Coding RNAs.
MA578945 - JP 2018138019-A/150871: Polycomb-Associated Non-Coding RNAs.
MA578946 - JP 2018138019-A/150872: Polycomb-Associated Non-Coding RNAs.
MA578947 - JP 2018138019-A/150873: Polycomb-Associated Non-Coding RNAs.
MA578948 - JP 2018138019-A/150874: Polycomb-Associated Non-Coding RNAs.
MA578949 - JP 2018138019-A/150875: Polycomb-Associated Non-Coding RNAs.
MA578951 - JP 2018138019-A/150877: Polycomb-Associated Non-Coding RNAs.
MA578952 - JP 2018138019-A/150878: Polycomb-Associated Non-Coding RNAs.
MA578954 - JP 2018138019-A/150880: Polycomb-Associated Non-Coding RNAs.
MA578955 - JP 2018138019-A/150881: Polycomb-Associated Non-Coding RNAs.
MA578956 - JP 2018138019-A/150882: Polycomb-Associated Non-Coding RNAs.
MA578957 - JP 2018138019-A/150883: Polycomb-Associated Non-Coding RNAs.
MA578958 - JP 2018138019-A/150884: Polycomb-Associated Non-Coding RNAs.
MA578959 - JP 2018138019-A/150885: Polycomb-Associated Non-Coding RNAs.
LF343383 - JP 2014500723-A/150886: Polycomb-Associated Non-Coding RNAs.
MA578960 - JP 2018138019-A/150886: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14195 (Reactome details) participates in the following event(s):

R-HSA-399944 Phosphorylation of CRMPs by Cdk5
R-HSA-399947 Tyrosine phosphorylation of CRMPs by Fes
R-HSA-399951 Phosphorylation of CRMPs by GSK3beta
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-373755 Semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: CRMP4, DRP3, NM_001197294, NP_001184223, Q14195-2, ULIP, ULIP1
UCSC ID: uc003loo.3
RefSeq Accession: NM_001197294
Protein: Q14195-2, splice isoform of Q14195 CCDS: CCDS56387.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001197294.1
exon count: 14CDS single in 3' UTR: no RNA size: 5496
ORF size: 2055CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4310.00frame shift in genome: no % Coverage: 99.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.