Human Gene HRH2 (uc003mdd.2)
  Description: Homo sapiens histamine receptor H2 (HRH2), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:175,108,464-175,111,558 Size: 3,095 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr5:175,110,237-175,111,316 Size: 1,080 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:175,108,464-175,111,558)mRNA (may differ from genome)Protein (359 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
HGNCLynxMalacardsMGIneXtProtPubMed
ReactomeTreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: HRH2_HUMAN
DESCRIPTION: RecName: Full=Histamine H2 receptor; Short=H2R; Short=HH2R; AltName: Full=Gastric receptor I;
FUNCTION: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
MISCELLANEOUS: Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Wikipedia; Note=H2 receptor entry; URL="http://en.wikipedia.org/wiki/H2_receptor";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): HRH2
CDC HuGE Published Literature: HRH2

-  MalaCards Disease Associations
  MalaCards Gene Search: HRH2
Diseases sorted by gene-association score: duodenal ulcer (54), peptic ulcer disease (37), gastric ulcer (34), zollinger-ellison syndrome (26), gastroesophageal reflux (24), esophagitis (23), laryngitis (21), aspiration pneumonitis (16), meckel's diverticulum (16), stomach disease (14), peptic esophagitis (12), active peptic ulcer disease (11), peptic ulcer perforation (11), dyspepsia (11), chronic laryngitis (10), gastritis (9), pancreatic cholera (8), interstitial nephritis (8), esophageal disease (7), suppurative lymphadenitis (7), laryngeal disease (6), functional gastric disease (5), systemic scleroderma (3), schizophrenia (2), asthma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.50 RPKM in Whole Blood
Total median expression: 37.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -599.331773-0.338 Picture PostScript Text
3' UTR -87.40242-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000503 - Histamine_H2_recept

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P25021
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004969 histamine receptor activity

Biological Process:
GO:0001696 gastric acid secretion
GO:0001697 histamine-induced gastric acid secretion
GO:0001698 gastrin-induced gastric acid secretion
GO:0003382 epithelial cell morphogenesis
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007613 memory
GO:0008542 visual learning
GO:0045907 positive regulation of vasoconstriction
GO:0048167 regulation of synaptic plasticity
GO:0048565 digestive tract development
GO:0048732 gland development
GO:1901998 toxin transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC054510 - Homo sapiens histamine receptor H2, mRNA (cDNA clone MGC:60198 IMAGE:6146988), complete cds.
AB591035 - Synthetic construct DNA, clone: pFN21AB7036, Homo sapiens HRH2 gene for histamine receptor H2, without stop codon, in Flexi system.
KJ891394 - Synthetic construct Homo sapiens clone ccsbBroadEn_00788 HRH2 gene, encodes complete protein.
KR712049 - Synthetic construct Homo sapiens clone CCSBHm_00035076 HRH2 (HRH2) mRNA, encodes complete protein.
JD150985 - Sequence 132009 from Patent EP1572962.
JD516629 - Sequence 497653 from Patent EP1572962.
JD324768 - Sequence 305792 from Patent EP1572962.
JD186615 - Sequence 167639 from Patent EP1572962.
JD355871 - Sequence 336895 from Patent EP1572962.
JD205542 - Sequence 186566 from Patent EP1572962.
JD215164 - Sequence 196188 from Patent EP1572962.
JD289080 - Sequence 270104 from Patent EP1572962.
JD195533 - Sequence 176557 from Patent EP1572962.
JD553715 - Sequence 534739 from Patent EP1572962.
JD328082 - Sequence 309106 from Patent EP1572962.
JD113905 - Sequence 94929 from Patent EP1572962.
JD185095 - Sequence 166119 from Patent EP1572962.
JD040984 - Sequence 22008 from Patent EP1572962.
AB451483 - Homo sapiens HRH2 mRNA for histamine receptor H2, partial cds, clone: FLJ80390SAAF.
AY136744 - Homo sapiens histamine receptor H2 (HRH2) mRNA, complete cds.
JD124581 - Sequence 105605 from Patent EP1572962.
JD124582 - Sequence 105606 from Patent EP1572962.
JD238582 - Sequence 219606 from Patent EP1572962.
JD061549 - Sequence 42573 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P25021 (Reactome details) participates in the following event(s):

R-HSA-390909 H2 receptor binds histamine
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-390650 Histamine receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B5BUP7, HRH2_HUMAN, NM_022304, NP_071640, P25021, Q14464, Q7Z5R9
UCSC ID: uc003mdd.2
RefSeq Accession: NM_022304
Protein: P25021 (aka HRH2_HUMAN or HH2R_HUMAN)
CCDS: CCDS4395.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022304.2
exon count: 1CDS single in 3' UTR: no RNA size: 3095
ORF size: 1080CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1483.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.