Human Gene MRNIP (uc003mlb.3)
  Description: Homo sapiens chromosome 5 open reading frame 45 (MRNIP), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:179,264,266-179,285,840 Size: 21,575 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr5:179,264,391-179,268,953 Size: 4,563 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:179,264,266-179,285,840)mRNA (may differ from genome)Protein (209 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HPRDLynxMGIneXtProtPubMedTreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: CE045_HUMAN
DESCRIPTION: RecName: Full=UPF0544 protein C5orf45;
SIMILARITY: Belongs to the UPF0544 family.
SEQUENCE CAUTION: Sequence=AAD51611.1; Type=Frameshift; Positions=191; Sequence=CAD97932.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.98 RPKM in Brain - Cerebellum
Total median expression: 397.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.91357-0.330 Picture PostScript Text
3' UTR -23.59125-0.189 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q6NTE8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0005515 protein binding

Biological Process:
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0010212 response to ionizing radiation
GO:0045860 positive regulation of protein kinase activity
GO:0071168 protein localization to chromatin
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2001032 regulation of double-strand break repair via nonhomologous end joining

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030870 Mre11 complex


-  Descriptions from all associated GenBank mRNAs
  LF209056 - JP 2014500723-A/16559: Polycomb-Associated Non-Coding RNAs.
BX537968 - Homo sapiens mRNA; cDNA DKFZp686L2452 (from clone DKFZp686L2452).
AK293901 - Homo sapiens cDNA FLJ56341 complete cds.
AK298954 - Homo sapiens cDNA FLJ59961 complete cds.
AB528169 - Synthetic construct DNA, clone: pF1KE0449, Homo sapiens C5orf45 gene for chromosome 5 open reading frame 45, without stop codon, in Flexi system.
AM392546 - Synthetic construct Homo sapiens clone IMAGE:100002180 for hypothetical protein (LOC51149 gene).
AM393590 - Synthetic construct Homo sapiens clone IMAGE:100002179 for hypothetical protein (LOC51149 gene).
BC050714 - Homo sapiens chromosome 5 open reading frame 45, mRNA (cDNA clone IMAGE:6146837), with apparent retained intron.
BC002739 - Homo sapiens chromosome 5 open reading frame 45, mRNA (cDNA clone IMAGE:3631869), partial cds.
AF153685 - Homo sapiens truncated calcium binding protein mRNA, complete cds.
BC056889 - Homo sapiens hypothetical LOC51149, mRNA (cDNA clone IMAGE:5764392).
BC069051 - Homo sapiens chromosome 5 open reading frame 45, mRNA (cDNA clone MGC:78537 IMAGE:3945859), complete cds.
BX647375 - Homo sapiens mRNA; cDNA DKFZp686B0310 (from clone DKFZp686B0310).
CR936785 - Homo sapiens mRNA; cDNA DKFZp781O2341 (from clone DKFZp781O2341).
AK095057 - Homo sapiens cDNA FLJ37738 fis, clone BRHIP2021762.
HQ447576 - Synthetic construct Homo sapiens clone IMAGE:100070918; CCSB014870_02 hypothetical LOC51149 (LOC51149) gene, encodes complete protein.
CU686703 - Synthetic construct Homo sapiens gateway clone IMAGE:100023165 5' read LOC51149 mRNA.
JD107969 - Sequence 88993 from Patent EP1572962.
AK295104 - Homo sapiens cDNA FLJ59885 complete cds.
JD452634 - Sequence 433658 from Patent EP1572962.
JD143939 - Sequence 124963 from Patent EP1572962.
JD470814 - Sequence 451838 from Patent EP1572962.
JD210321 - Sequence 191345 from Patent EP1572962.
MA444633 - JP 2018138019-A/16559: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B5MD09, BC056889, C5orf45, CE045_HUMAN, Q6NTE8, Q7Z3D8, Q9BUC1, Q9UN54
UCSC ID: uc003mlb.3
RefSeq Accession: NM_016175
Protein: Q6NTE8 (aka CE045_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC056889.1
exon count: 6CDS single in 3' UTR: no RNA size: 1171
ORF size: 630CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 973.00frame shift in genome: no % Coverage: 90.09
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 494# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.